Groupings

A curated hierarchy, not an inferred one. A child rolls up to its parent for counting and keeps its own identity — dyspareunia and osteoporosis are both menopause, and a reader looking for one does not want the other.

• Heart failure — 2 narrower indications, and 9 graded rows of its own
• Hyperglycaemia — 1 narrower indication, and 10 graded rows of its own
• Hyperpigmentation — 1 narrower indication, and 3 graded rows of its own
• Menopause — 8 narrower indications, and 5 graded rows of its own
• Pain — 2 narrower indications, and 4 graded rows of its own
• Skin ageing — 3 narrower indications, and 5 graded rows of its own
• Weight — 5 narrower indications, and no rows of its own

Rung and directness are two different judgements

The rung rates the study design and says nothing about what was measured. Directness rates what was measured and says nothing about how well. A randomised human trial that measured a mitochondrial marker is a human RCT and it is not evidence about the condition, so every row carries both.

Direct outcome

The study measured the condition itself, or a symptom a patient would report. direct_outcome

Surrogate marker

It measured a biological marker accepted as standing in for the condition, not the condition. surrogate_marker

Mechanistic only

It measured something upstream. The link to the condition is an argument, not a result — these rows are recorded and labelled, never presented as evidence for the condition. mechanistic_only

Approval is per condition, and per population

An approval next door is not an approval here. A compound approved for premenopausal women is not_approved on a menopause row, with the adjacent approval explained in the note — collapsing that distinction is how a record turns into a recommendation.

Approved for this condition

A national regulator approved it for this condition. The note names the regulator. approved

Off-label use

Approved for something else, and prescribed for this. off_label

In registered trials

In registered clinical trials for this condition, and not approved. investigational

Not approved for this condition

No approval for this condition anywhere. This is the common case. not_approved

Approval not established

We could not establish an approval status. The note says what was checked. unknown