IGF-1 LR3

Mechanism

Modified IGF-1 with extended half-life affecting PI3K-Akt-mTOR and satellite cells.

Reported effects

What sources associate with this compound. Reported categories, not outcomes we have graded — each would need its own citation and rung.

• Muscle repair
• Satellite-cell activation
• Collagen synthesis

Half-life, storage & sport

Elimination half-life

not on file — No half-life is on file in any species. A 2026 review of performance-enhancing peptides acting on the GH-IGF-1 axis states the absence in its own table: no peer-reviewed human study reports even the route of administration. The circulated figure of 20 to 30 hours traces to supplier copy and dosing calculators, and the animal work points the other way. Ballard 1993 found LR3IGF-I cleared from rat plasma much faster than IGF-1, because escaping IGF-binding-protein capture is what shortens a half-life rather than lengthening it.

Storage

Lyophilised: Stable at room temperature ~3 weeks; store desiccated below -18C. Reconstituted: Reconstitute in sterile 18 Mohm-cm H2O at 100 ug/mL; 4C for 2-7 days; below -18C for future use; 0.1% HSA/BSA for long term. — source. ProSpec Long R3 IGF-1 technical datasheet. Supplier handling recommendation for research-grade lyophilate, not a per-compound stability study.

In sport (WADA 2026)

Prohibited, at all times — named S2.3 (IGF-1 and its analogues). the list LR3 is an IGF-1 analogue, squarely inside the named class.

Literature on file 7

• human case series
  Detection of His-tagged Long-R3-IGF-I in a black market product (Growth Hormone & IGF Research 2010, cited 33x) graded on: a case report or series — read from the indexed abstract — “case report”
• animal in vivo
  Long R3 insulin-like growth factor-I (IGF-I) infusion stimulates organ growth but reduces plasma IGF-I, IGF-II and IGF binding protein concentrations in the guinea pig (Journal of Endocrinology 1995, cited 20x) graded on: an animal model — “pig”
• review or editorial
  The emerging landscape of performance-enhancing peptides modulating GH-IGF1 axis: bridging the gap between clinical evidence and patient self-administration. graded on: indexed as "review-article" - secondary literature, not a study — “review-article”
• review or editorial
  Therapeutic Peptides in Aesthetic, Metabolic and Endocrine Conditions: Effects, Safety, Clinical Applications, and Future Perspectives. graded on: indexed as "review-article" - secondary literature, not a study — “review-article”
• in vitro
  IGF-1 Increases Collagen Deposition by Dermal Fibroblasts: Applications for Tissue Engineering. graded on: an in-vitro system — read from the indexed abstract — “cultured”
• animal in vivo
  IGF-1 LR3 does not promote growth in late-gestation growth-restricted fetal sheep. graded on: an animal model — “sheep”
• animal in vivo
  Revolutionary decellularized Alstroemeria stem-based nerve conduit integrated with GelMA and controlled IGF-1 LR3 release for enhanced rat sciatic nerve regeneration. graded on: an animal model — “rat”

Identity

Classified as

mTOR Signalingmechanism

Direction matters more here than almost anywhere else on the site. The muscle literature is interested in raising mTOR activity and the longevity literature in lowering it, and one word covers both, so the record has to state which.

Growth Hormone / IGF-1 Axispathway

The lab value people actually track, IGF-1 in ng/mL, sits two steps downstream of where most of these compounds act, so a record's mechanism and its measurable marker are rarely the same thing.

Subcutaneousroute

This is the route the reconstitution arithmetic assumes. Mass divided by diluent volume gives concentration, dose divided by concentration gives volume, and volume in mL multiplied by 100 gives units on a U-100 barrel: 5 mg in 2 mL is 2.5 mg/mL, and 0.25 mg comes out at 0.1 mL, which is 10 units.

Also called

• IGF-1 LR3
• igf lr3
• igf lr3 –

Listed prices 192

What 141 shops we track listed for IGF-1 LR3, read from their own public catalogues on 2026-09-14. We take no commission on these and they are not ranked by any payment — how vendors are scored.