Semax

Mechanism

ACTH analog associated with BDNF up-regulation and dopaminergic modulation.

Reported effects

What sources associate with this compound. Reported categories, not outcomes we have graded — each would need its own citation and rung.

• Cognitive drive
• Focus enhancement
• Post-TBI support

Reconstitution

mass ÷ diluent = concentration; dose ÷ concentration = volume; volume × the syringe factor = units on the barrel (100 for U-100, 40 for U-40). Run your own numbers.

Half-life, storage & sport

Elimination half-life

not on file — no primary pharmacokinetic study found.

Storage

Lyophilised: Stable at room temperature ~3 weeks; store desiccated below -18C. Reconstituted: 4C for 2-7 days; below -18C for future use; 0.1% HSA/BSA for long term; avoid freeze-thaw. — source. ProSpec technical datasheet. Supplier handling recommendation for research-grade lyophilate, not a per-compound stability study.

In sport (WADA 2026)

not recorded as a yes or no — not named; S0 turns on whether Russian approval counts at all times if S0 applies the list Same analysis as Selank: registered in Russia, no approval elsewhere. Status not determinable from the list text; check GlobalDRO.

Reported adverse effects

• Limited safety data outside Russian clinical use

  N/Aonset: N/Areversibility not on file

Literature on file 6

• review or editorial
  Therapeutic peptides in gerontology: mechanisms and applications for healthy aging. graded on: indexed as "review-article" - secondary literature, not a study — “review-article”
• review or editorial
  Therapeutic Peptides in Aesthetic, Metabolic and Endocrine Conditions: Effects, Safety, Clinical Applications, and Future Perspectives. graded on: indexed as "review-article" - secondary literature, not a study — “review-article”
• animal in vivo
  The Potential of the Peptide Drug Semax and Its Derivative for Correcting Pathological Impairments in the Animal Model of Alzheimer's Disease. graded on: an animal model — “Animal Model”
• animal in vivo
  The Effect of Peptide Semax, an ACTH(4-10) Analogue, on Intracellular Calcium Dynamics in Rat Brain Neurons. graded on: an animal model — “Rat”
• animal in vivo
  Semax peptide targets the μ opioid receptor gene Oprm1 to promote deubiquitination and functional recovery after spinal cord injury in female mice. graded on: an animal model — “mice”

Not graded

1 citation whose study design could not be read from the title. Left ungraded rather than guessed at.

• not graded
  Neuropeptide semax — Effective antithrombotic drug (2002, cited 1x)

What is circulated not evidence 5

Claims passed around in community guides and vendor copy, recorded because they circulate — not because they are true. Each is shown with the page it was read from and what this record actually holds. Checked 2026-08-24.

• unverified community data dose ubiquitous contradicts the record

  300 mcg per nostril in the morning, giving 600 mcg a day, is the usual starting point in community guides, with escalation to 900 and sometimes 1200 mcg daily.

  300 mcg per nostril

  On the record The record holds 200-600 mcg per administration daily, and marks it unverified. The circulated 900 and 1200 mcg daily totals sit above the top of the range on file, and the record does not distinguish per-administration from per-day.

  Source 1 · Source 2

• unverified community data dose common contradicts the record

  Wider guides give 250 to 1000 mcg per administration, one to three times daily, with daily totals of 500 to 3000 mcg attributed to Russian clinical protocols.

  300 mcg per nostril

  On the record The record caps at 600 mcg per administration. A 3000 mcg daily total is five times that, and no Russian protocol, no dose frequency and no clinical source for either is on file. The record's grading rests simply on an animal model.

  Source 1 · Source 2

• unverified community data titration common nothing on file either way

  Ten to fourteen days on and seven to ten days off, up to three cycles before a thirty-day break, is the cycling pattern given.

  10 to 14 days on, 7 to 10 days off.

  On the record The record holds a cycle low of two weeks and no upper bound. The two-week course matches; the off-period, the cycle count and the thirty-day break are not on file.

  Source 1

• unverified community data side effect occasional nothing on file either way

  Semax is described as well tolerated at doses up to 9 mg daily, with nasal dryness and transient headache the only effects named.

  well tolerated at doses up to 9 mg daily

  On the record The record holds one side-effect entry, 'Limited safety data outside Russian clinical use'. A 9 mg daily tolerability figure is fifteen times the top of the dose range on file and appears nowhere in the record.

  Source 1

• unverified community data dose common nothing on file either way

  Subcutaneous injection is offered as an alternative route in dosing guides alongside the nasal spray.

  300 mcg per nostril

  On the record The record lists 'Intranasal' as the only route for semax. The subcutaneous route being sold and dosed is not on file, and no half-life is on file for either route.

  Source 1 · Source 2

Identity

PubChem CID 9811102 computed 3D conformer

Skeletal formulathe canonical depiction

Drawn by PubChem from CID 9811102, the identifier on this record.

Molecular weight

813.9

Molecular formula

C37H51N9O10S

CAS number

80714-61-0

PubChem CID

9811102

InChI key

AFEHBIGDWIGTEH-AQRCPPRCSA-N

Sequence

MEHFPGP

SMILES

CSCC[C@@H](C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CC1=CN=CN1)C(=O)N[C@@H](CC2=CC=CC=C2)C(=O)N3CCC[C@H]3C(=O)NCC(=O)N4CCC[C@H]4C(=O)O)N

InChI

InChI=1S/C37H51N9O10S/c1-57-16-13-24(38)32(50)42-25(11-12-31(48)49)33(51)43-26(18-23-19-39-21-41-23)34(52)44-27(17-22-7-3-2-4-8-22)36(54)46-15-5-9-28(46)35(53)40-20-30(47)45-14-6-10-29(45)37(55)56/h2-4,7-8,19,21,24-29H,5-6,9-18,20,38H2,1H3,(H,39,41)(H,40,53)(H,42,50)(H,43,51)(H,44,52)(H,48,49)(H,55,56)/t24-,25-,26-,27-,28-,29-/m0/s1

Classified as

Dopaminergic Modulationmechanism

Records claiming drive, motivation or focus usually point here, and the honest version of such a claim names the step in the system rather than the feeling it is meant to produce.

BDNF/TrkB Signalingmechanism

Nearly every nootropic record on the site points here, so it is where a cognitive claim can be checked against something measurable instead of taken as a description of how someone felt.

Intranasalroute

A nasal device delivers a fixed volume per spray, so concentration rather than syringe volume sets the amount per spray, and a mass figure on a record is not usable until you know how many actuations it was divided across.

Also called

• Semax
• Semax (Stress)

Listed prices 329

What 189 shops we track listed for Semax, read from their own public catalogues on 2026-09-14. We take no commission on these and they are not ranked by any payment — how vendors are scored.

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