Cardiovascular & General

Angiotensin (1-7)

The renin-angiotensin system is usually described as the body's accelerator on blood pressure, and angiotensin (1-7) is the brake built into the same machinery: a seven-amino-acid fragment with its own receptor, opposing the arm that tightens vessels. In rats with acid-injured lungs it nearly halved the collagen laid down, and that anti-scarring biology carried it into a randomised trial in severe COVID-19. Then it was infused directly into the arms of eight patients with heart failure and did nothing measurable: no widening of vessels on its own, no change to the response to bradykinin, and the authors concluded it was biologically inactive in that circulation.

Last updated 12 August 2026

Studied forVasodilation research · Anti-fibrotic research · Inflammation modulation context

Evidence on file1 randomised human trial · 1 in-vitro study

Strongest sourceNCT04401423: Randomized Controlled Trial of Angiotensin 1-7 (TXA127) for the Treatment of Severe COVID-19 (randomised human trial)

Mechanism

Binds the Mas receptor, opposing AT1 signalling with vasodilation and reduced fibrotic and inflammatory activity.

Reported effects

What sources associate with this compound. Reported categories, not outcomes we have graded — each would need its own citation and rung.

Vasodilation research
Anti-fibrotic research
Inflammation modulation context

Dosing on file unverified

COVID-19 ICU: start 5 mcg/kg/day → increase to 10 mcg/kg/day after 24h; COVID-19 ICU: start 5 mcg/kg/day → 10 mcg/kg/day; PAD: 1, 2, 4, 8, 12 ng/kg/min escalating; TXA-127: 0.5 mg/kg/day × 5-10 days

Carried from a source that labels it unverified, and reproduced with that label attached. A record of what is reported, not a recommendation. No citation on this page establishes it.

Literature on file 2

human RCT
NCT04401423: Randomized Controlled Trial of Angiotensin 1-7 (TXA127) for the Treatment of Severe COVID-19 graded on: names a randomised controlled trial — “Randomized Controlled”
in vitro
Angiotensin (1-7) Induces Mas Receptor Internalization (Hypertension 2011, cited 81x) graded on: MasR-YFP transfected HEK 293T cells, confocal imaging — read from the abstract — “abstract review”

Identity

Space-filling 3D model of Angiotensin (1-7), carbon grey, nitrogen blue, oxygen red — Built from the SMILES on this record — the atoms and bonds are exact. The shape is **one computed low-energy pose**, not a measured structure: a flexible peptide in solution has no single conformation, and where the SMILES leaves a stereocentre undefined the pose commits to one arbitrarily. The skeletal formula below claims connectivity and nothing more, which is what we actually know.

2D chemical structure of Angiotensin (1-7) — Built from the SMILES on this record — the atoms and bonds are exact. The shape is **one computed low-energy pose**, not a measured structure: a flexible peptide in solution has no single conformation, and where the SMILES leaves a stereocentre undefined the pose commits to one arbitrarily. The skeletal formula below claims connectivity and nothing more, which is what we actually know.

Molecular weight: 899.0
Molecular formula: C41H62N12O11
CAS number: 51833-78-4
PubChem CID: 123805
InChI key: PVHLMTREZMEJCG-GDTLVBQBSA-N
SMILES: CC[C@H](C)[C@@H](C(=O)N[C@@H](CC1=CN=CN1)C(=O)N2CCC[C@H]2C(=O)O)NC(=O)[C@H](CC3=CC=C(C=C3)O)NC(=O)[C@H](C(C)C)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC(=O)O)N
InChI: InChI=1S/C41H62N12O11/c1-5-22(4)33(38(61)50-29(17-24-19-45-20-47-24)39(62)53-15-7-9-30(53)40(63)64)52-36(59)28(16-23-10-12-25(54)13-11-23)49-37(60)32(21(2)3)51-35(58)27(8-6-14-46-41(43)44)48-34(57)26(42)18-31(55)56/h10-13,19-22,26-30,32-33,54H,5-9,14-18,42H2,1-4H3,(H,45,47)(H,48,57)(H,49,60)(H,50,61)(H,51,58)(H,52,59)(H,55,56)(H,63,64)(H4,43,44,46)/t22-,26-,27-,28-,29-,30-,32-,33-/m0/s1

Notes unverified prose

Phase 1/2; NCT04401423

Not on file 2

1 of the 8 fields we track hold nothing on this record, and each says why. 1 further absence is named below. A blank field is a bug; a named absence is a finding.

amino-acid sequencenothing we hold supplies it
half-lifenothing we hold supplies it

Each field links to every other record missing the same thing. The full ledger holds 765 gaps across 163 records.

Listed prices 5

What 2 shops we track listed for Angiotensin (1-7), read from their own public catalogues on 2026-09-14. We take no commission on these and they are not ranked by any payment — how vendors are scored.

Compare prices5 listings from 2 shops

Listed in USD
Vendor	Size	Price	Per mg
QSC (Qingdao Sigma Chemical) ships worldwide	20 mg	$110.00 USD	$5.50/mg
QSC (Qingdao Sigma Chemical) ships worldwide	10 mg	$100.00 USD	$10.00/mg
QSC (Qingdao Sigma Chemical) ships worldwide	2.5 mg	$100.00 USD	$40.00/mg
rPeptide	size not listed	$128.00 USD	—
rPeptide	size not listed	$498.00 USD	—

Prices are the vendor's own listing, reproduced with the date we read it — never converted between currencies, and compared per milligram only where the vendor states the vial size.