Immune & Antimicrobial
Temporins
Temporins are among the smallest antimicrobial peptides known, drawn from frog skin secretions, and they work across an unusually wide range for their size: Gram-positive bacteria, fungi, and the parasites that cause leishmaniasis. The mouse result is unambiguous. A temporin combination given to mice with bloodstream Staphylococcus aureus and Salmonella infections kept them alive to day 28 and cleared their organs within days, while untreated animals died within a week, and it still worked when treatment was delayed to day seven. That result is real, and it is exactly where the record stops: no temporin has ever been given to a human being, none is in clinical development, and the whole published literature on file runs to 29 papers.
Last updated
Mechanism
Fold into amphipathic helices on contact with microbial membranes and permeabilise them, chiefly in Gram-positive bacteria.
Reported effects
What sources associate with this compound. Reported categories, not outcomes we have graded — each would need its own citation and rung.
- Antibacterial research
- Antifungal and antiparasitic studies
- Membrane permeabilisation studies
Dosing on file unverified
No established human dose; no clinical development
Carried from a source that labels it unverified, and reproduced with that label attached. A record of what is reported, not a recommendation. No citation on this page establishes it.
Literature on file 6
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animal in vivo
Temporins, Small Antimicrobial Peptides with Leishmanicidal Activity (2005, cited 175x) graded on: an animal model — read from the indexed abstract — “frog”
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review or editorial
Chemical Optimization of Temporin A-L Peptides: From Native Isoforms to Enhanced Antimicrobial Analogs. graded on: indexed as "Review" - secondary literature, not a study — “Review”
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in vitro
Antimicrobial Activity of Bioactive Peptides on Resistant Enterobacteriaceae and the Viability of Giardia duodenalis Cysts Isolated from Healthy Dogs. graded on: an in-vitro system — read from the indexed abstract — “in vitro”
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in vitro
Antimicrobial Peptides Induce Cell Death in Marginal Zone Lymphoma Models Resistant to Targeted Therapies. graded on: synthesised peptides tested against marginal zone lymphoma cell lines — read from the abstract — “abstract review”
- animal in vivo
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in vitro
Design and Mode of Action of a New Synthetic Antibacterial Peptide against Pseudomonas aeruginosa. graded on: an in-vitro system — read from the indexed abstract — “assay”
Notes unverified prose
No temporin ever tested in humans; no clinical development for any temporin variant; No human trials; no clinical development
Not on file 10
8 of the 8 fields we track hold nothing on this record, and each says why. 2 further absences are named below. A blank field is a bug; a named absence is a finding.
- molecular weightnothing we hold supplies it
- molecular formulanothing we hold supplies it
- CAS registry numbernothing we hold supplies it
- PubChem identifiernothing we hold supplies it
- amino-acid sequencenothing we hold supplies it
- SMILES stringnothing we hold supplies it
- InChInothing we hold supplies it
- InChI keynothing we hold supplies it
- half-lifenothing we hold supplies it
- route of administrationnothing we hold supplies it
Each field links to every other record missing the same thing. The full ledger holds 765 gaps across 163 records.