Metabolic & Weight Management
Nesfatin-1
Nesfatin-1 is a fragment cut from a larger protein, NUCB2, and found in the hypothalamus, where it acts to reduce eating. The finding that earned it attention is a clean one: injected into rat brain ventricles it cut food intake dose-dependently, an antibody that mopped it up increased intake, and, the important part, the effect survived in Zucker rats, whose leptin receptors do not work. It suppresses appetite without needing leptin, running through melanocortin signalling instead. In people it appears as a measurement rather than a dose, a blood marker that tracks metabolic and stress states. The record states there is no established human dose and no controlled dosing trial, and classes it as an endogenous molecule rather than a therapeutic.
Last updated
Mechanism
Acts centrally through melanocortin-3/4 and CRF2 receptor signalling and hyperpolarises orexigenic neuropeptide Y neurons.
Reported effects
What sources associate with this compound. Reported categories, not outcomes we have graded — each would need its own citation and rung.
- Appetite regulation research
- Glucose metabolism context
- Stress axis marker
Dosing on file unverified
No validated human dose (animal: 70 µg/mouse)
Carried from a source that labels it unverified, and reproduced with that label attached. A record of what is reported, not a recommendation. No citation on this page establishes it.
Literature on file 7
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review or editorial
Nesfatin-1 across human reproduction and early life: implications for infertility, pregnancy complications, and lactation. graded on: indexed as "review-article" - secondary literature, not a study — “review-article”
- animal in vivo
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animal in vivo
Identification of Nesfatin-1 in primitive vertebrate lampreys and its roles in inflammatory responses and ferroptosis. graded on: lamprey nesfatin-1 cloning with LPS challenge and expression readouts — read from the abstract — “abstract review”
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animal in vivo
Transcriptomic and metabolomic analyses revealed the action mechanism of nesfatin-1 gene on glucolipid metabolism during early development stage of largemouth bass. graded on: siRNA knockdown of nesfatin-1 in larval largemouth bass with transcriptomics and metabolomics — read from the abstract — “abstract review”
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human observational
Relationship of serum nesfatin-1 levels with body mass index and c-reactive protein in patients presenting to the emergency department with epileptic seizures. graded on: an observational human design — read from the indexed abstract — “cross-sectional”
Not graded
2 citations whose study design could not be read from the title. Left ungraded rather than guessed at.
- not graded
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not graded
NCT04298515: Determination of the Relationship Between Nesfatin-1 Levels and Energy Intake Levels of Patients With Type 2 Diabetes, Insulin Resistance and Obesity graded on: NCT04298515 is unknown and has posted no results - a registration, not a reported outcome — “NCT04298515”
Notes unverified prose
No controlled human dosing trials; observational only; No therapeutic trials; biomarker studies only
Not on file 10
8 of the 8 fields we track hold nothing on this record, and each says why. 2 further absences are named below. A blank field is a bug; a named absence is a finding.
- molecular weightnothing we hold supplies it
- molecular formulanothing we hold supplies it
- CAS registry numbernothing we hold supplies it
- PubChem identifiernothing we hold supplies it
- amino-acid sequencenothing we hold supplies it
- SMILES stringnothing we hold supplies it
- InChInothing we hold supplies it
- InChI keynothing we hold supplies it
- half-lifenothing we hold supplies it
- route of administrationnothing we hold supplies it
Each field links to every other record missing the same thing. The full ledger holds 765 gaps across 163 records.