PEPTIDE CORPUS

Metabolic & Weight Management

Cagrilintide

Space-filling model of Cagrilintide

Cagrilintide is a manufactured amylin, the pancreatic fullness hormone, engineered to last: its half-life is about a week where the natural peptide is cleared in minutes. It exists mostly to be given with semaglutide, a combination called CagriSema, on the reasoning that two different satiety signals do more than one. A phase 2 trial put numbers on that: cagrilintide alone moved HbA1c by 0.9 percentage points, semaglutide alone by 1.8, and the pair by 2.2. The evidence behind it is substantial and recent, running to four phase 3 randomised trials across type 2 diabetes and obesity on top of a 706-person dose-finding study. No regulator has approved it, alone or in combination.

Last updated

Studied forBody weight research · Appetite regulation research · Glycaemic control context
Evidence on file5 randomised human trials · 1 human observational study · 4 citations not yet graded
Strongest sourceCagrilintide-semaglutide (CagriSema) as an add-on to basal insulin in adults with type 2 diabetes (REIMAGINE… (randomised human trial)

Mechanism

Agonist at amylin AMY1 and AMY3 receptors in the hindbrain, and at the calcitonin receptor, reducing food intake.

Reported effects

What sources associate with this compound. Reported categories, not outcomes we have graded — each would need its own citation and rung.

  • Body weight research
  • Appetite regulation research
  • Glycaemic control context

Figures

Every figure below is replotted by this site from values published in the cited paper's text or tables — the numbers are the study's, the drawing is ours, and the evidence rung on each image is the rung of its source.

Weight change at week 26 — cagrilintide 4.5 mg phase 2 — Week 26, Mean body-weight change (%) by treatment
Data: Lau et al. 2021, Lancet (cagrilintide dose-finding) · n=706. Trial-product estimand. The full 0.3–4.5 mg dose ladder appears in the abstract only as a range (6.0%–10.8%), so intermediate doses are omitted rather than guessed.
Weight change at week 68 — REDEFINE 1 — Week 68, Estimated mean body-weight change at week 68 (%) by treatment
Data: Garvey et al. 2025, NEJM (REDEFINE 1) · n=3417 adults with overweight or obesity and without diabetes: 2108 cagrilintide-semaglutide, 302 semaglutide, 302 cagrilintide, 705 placebo. Estimated difference -17.3 percentage points (95% CI -18.1 to -16.6). The two monotherapy arms are not given numerically in the abstract, so they are not plotted. Gastrointestinal adverse events affected 79.6% vs 39.9%.
Cagrilintide-semaglutide vs semaglutide alone — REDEFINE 5 — Week 68, Estimated mean body-weight change at week 68 (%) by treatment
Data: Yamauchi et al. 2026, Lancet Diabetes Endocrinol (REDEFINE 5, Japan and Taiwan) · n=331 across 22 sites in Japan and Taiwan: 164 cagrilintide-semaglutide, 167 semaglutide. Active-controlled phase 3a, so there is no placebo arm. Published as -18.4% (SE 0.7) vs -11.9% (SE 0.7).

Dosing on file unverified

Titrate to 2.4 mg/week

Carried from a source that labels it unverified, and reproduced with that label attached. A record of what is reported, not a recommendation. No citation on this page establishes it.

What is circulated about this dose. One claim is recorded on this page with the page it was read from. Read what is circulated.

Half-life, storage & sport

Elimination half-life
159-195 hours (human, SC) — study. phase 1b, cagrilintide 0.16-4.5 mg with semaglutide 2.4 mg, Lancet 2021.
Storage
not on file — no stability record on file — investigational, no label.
In sport (WADA 2026)
Prohibited, at all times — S0 catch-all. the list Not named; investigational, no approval for human therapeutic use.

The half-life on file is 1.1 wk, measured subcutaneously. No dosing schedule could be read from this record, so the curve below is one dose drawn from the moment it is given. Nothing here says how often it is repeated.

One dose. 5.3 wk of decay, normalised to its own peak.
1 compounds on one time axis, each normalised to its own peak0%25%50%75%100%0 min1.3 wk2.6 wk4 wk5.3 wkpeaktime from the first doseCagrilintide

The rise is not modelled and the axis is not a blood level. No absorption rate constant and no volume of distribution are on file, so each dose appears at full height the instant it is given, and the axis is percent of this compound's own peak.

Literature on file 11

Not graded

4 citations whose study design could not be read from the title. Left ungraded rather than guessed at.

What is circulated not evidence 4

Claims passed around in community guides and vendor copy, recorded because they circulate — not because they are true. Each is shown with the page it was read from and what this record actually holds. Checked 2026-08-24.

  • unverified community data titration common nothing on file either way

    A 16-week escalation ladder to a 2.4 mg weekly target, in 4-week steps, is circulated as the standalone cagrilintide protocol.

    It uses a 16-week escalation ladder so tolerability can be reviewed before the 2.4 mg weekly research-target dose.

    On the record No dosing record exists on file for cagrilintide at all; the ladder is a community construction from trial arms.

    Source 1

  • unverified community data stacking common nothing on file either way

    Stacking cagrilintide with semaglutide to reproduce CagriSema at home is circulated, citing the REDEFINE 1 weight-loss figures as the rationale.

    the combination produced 20.4% mean weight loss versus 11.8% for cagrilintide alone and 14.9% for semaglutide alone

    On the record The record holds cagrilintide's own trial benefits (body weight, appetite regulation, glycaemic context); no co-formulation or home-stacking record exists.

    Source 1

  • unverified community data storage common nothing on file either way

    Vendor protocol pages state reconstituted cagrilintide keeps 28-30 days refrigerated and must not be frozen.

    use within 28-30 days. Do not freeze the reconstituted solution.

    On the record Storage on file: no stability record — investigational, no label. The circulated figure has no study behind it.

    Source 1

  • unverified community data side effect common cannot be checked

    High nausea and injection-site reaction rates from the phase 2 trial are circulated on vendor pages as expected side effects.

    nausea occurred in 47% of participants, injection-site reactions in 43%

    On the record The record holds trial-derived benefit and tolerability context; the specific percentage figures should be checked against the cited Lancet 2021 trial before any use.

    Source 1

Identity

PubChem CID 171397054 computed 3D conformer Space-filling 3D model of Cagrilintide, carbon grey, nitrogen blue, oxygen red
Built from the SMILES on this record — the atoms and bonds are exact. The shape is one computed low-energy pose, not a measured structure: a flexible peptide in solution has no single conformation, and where the SMILES leaves a stereocentre undefined the pose commits to one arbitrarily. The skeletal formula below claims connectivity and nothing more, which is what we actually know.
Skeletal formulathe canonical depiction
2D chemical structure of Cagrilintide

Drawn by PubChem from CID 171397054, the identifier on this record.

Molecular weight
4409
Molecular formula
C194H312N54O59S2
CAS number
1415456-99-3
PubChem CID
171397054
UniProt
P10997
InChI key
LDERDVMBIYGIOI-IZVMHKDJSA-N
Sequence
XKCNTATCATQRLAEFLRHSSNNFGPILPPTNVGSNTP
SMILES
CC[C@H](C)[C@@H](C(=O)N[C@H](CC(C)C)C(=O)N1CCC[C@@H]1C(=O)N2CCC[C@@H]2C(=O)N[C@H]([C@H](C)O)C(=O)N[C@H](CC(=O)N)C(=O)N[C@H](C(C)C)C(=O)NCC(=O)N[C@H](CO)C(=O)N[C@H](CC(=O)N)C(=O)N[C@H]([C@H](C)O)C(=O)N3CCC[C@@H]3C(=O)N)NC(=O)[C@@H]4CCCN4C(=O)CNC(=O)[C@H](CC5=CC=CC=C5)NC(=O)[C@H](CC(=O)N)NC(=O)[C@H](CC(=O)N)NC(=O)[C@H](CO)NC(=O)[C@H](CO)NC(=O)[C@H](CC6=CNC=N6)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC7=CC=CC=C7)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@@H](C)NC(=O)[C@@H](CC(C)C)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CCC(=O)N)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](C)NC(=O)[C@@H]8CSSC[C@@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N8)[C@@H](C)O)C)[C@@H](C)O)CC(=O)N)NC(=O)[C@H](CCCCN)NC(=O)CC[C@@H](C(=O)O)NC(=O)CCCCCCCCCCCCCCCCCCC(=O)O
InChI
InChI=1S/C194H312N54O59S2/c1-19-100(10)151(184(298)233-128(78-98(6)7)189(303)248-75-49-60-137(248)190(304)247-74-48-59-136(247)182(296)243-155(107(17)255)187(301)232-127(86-143(201)262)173(287)238-150(99(8)9)183(297)210-88-146(265)218-129(90-249)176(290)230-126(85-142(200)261)175(289)244-156(108(18)256)191(305)246-73-46-57-134(246)157(202)271)239-181(295)135-58-47-72-245(135)147(266)89-211-161(275)120(79-109-50-36-34-37-51-109)225-171(285)123(82-139(197)258)228-172(286)124(83-140(198)259)229-177(291)130(91-250)235-178(292)131(92-251)234-170(284)122(81-111-87-207-95-212-111)227-164(278)114(56-45-71-209-194(205)206)221-168(282)119(77-97(4)5)224-169(283)121(80-110-52-38-35-39-53-110)226-166(280)116(65-68-149(269)270)219-158(272)101(11)213-167(281)118(76-96(2)3)223-163(277)113(55-44-70-208-193(203)204)220-165(279)115(63-66-138(196)257)222-186(300)153(105(15)253)240-159(273)102(12)214-179(293)132-93-308-309-94-133(180(294)231-125(84-141(199)260)174(288)242-152(104(14)252)185(299)215-103(13)160(274)241-154(106(16)254)188(302)237-132)236-162(276)112(54-42-43-69-195)216-145(264)67-64-117(192(306)307)217-144(263)61-40-32-30-28-26-24-22-20-21-23-25-27-29-31-33-41-62-148(267)268/h34-39,50-53,87,95-108,112-137,150-156,249-256H,19-33,40-49,54-86,88-94,195H2,1-18H3,(H2,196,257)(H2,197,258)(H2,198,259)(H2,199,260)(H2,200,261)(H2,201,262)(H2,202,271)(H,207,212)(H,210,297)(H,211,275)(H,213,281)(H,214,293)(H,215,299)(H,216,264)(H,217,263)(H,218,265)(H,219,272)(H,220,279)(H,221,282)(H,222,300)(H,223,277)(H,224,283)(H,225,285)(H,226,280)(H,227,278)(H,228,286)(H,229,291)(H,230,290)(H,231,294)(H,232,301)(H,233,298)(H,234,284)(H,235,292)(H,236,276)(H,237,302)(H,238,287)(H,239,295)(H,240,273)(H,241,274)(H,242,288)(H,243,296)(H,244,289)(H,267,268)(H,269,270)(H,306,307)(H4,203,204,208)(H4,205,206,209)/t100-,101+,102-,103-,104+,105+,106+,107-,108-,112-,113-,114-,115-,116-,117-,118+,119-,120-,121-,122-,123-,124-,125-,126+,127+,128+,129+,130-,131-,132-,133-,134+,135-,136+,137+,150+,151-,152-,153-,154-,155+,156+/m0/s1

Also called

  • cagri
  • cagrilinitide
  • cag

Notes unverified prose

Phase 2; Phase 2/3; REDEFINE trials

Not on file 0

All 8 tracked fields hold a value on this record: molecular weight and formula, CAS number, PubChem CID, amino-acid sequence, SMILES, InChI and InChI key.

Counted from the record itself, not from what a source said it was missing. 163 of 188 records still have at least one empty.

Listed prices 169

What 104 shops we track listed for Cagrilintide, read from their own public catalogues on 2026-09-14. We take no commission on these and they are not ranked by any payment — how vendors are scored.

Compare prices169 listings from 104 shops
Listed in USD
VendorSizePricePer mg
Step One Ventures 10 mg $49.00 USD $4.90/mg
IDUN Peptides 10 mg $49.99 USD $5.00/mg
Novaglo Research 5 mg $25.00 USD $5.00/mg
Novaglo Research 10 mg $50.00 USD $5.00/mg
Peptide Partners 200 mg $1050.00 USD $5.25/mg
research1peptides 10 mg $55.00 USD $5.50/mg
Peptide Partners 150 mg $835.00 USD $5.57/mg
Step One Ventures 5 mg $29.00 USD $5.80/mg
research1peptides 5 mg $30.00 USD $6.00/mg
Peptide Partners 100 mg $610.00 USD $6.10/mg
Elite Edge Biotech 10 mg $63.00 USD $126.00 USD $6.30/mg
AMC Essentials 20 mg $129.99 USD $6.50/mg
Rejuven8 Peptides 10 mg $65.00 USD $80.00 USD $6.50/mg
Peptide Partners 50 mg $335.00 USD $6.70/mg
Evolve BioPep 5 mg $34.99 USD $7.00/mg
Double R Labs 10 mg $69.99 USD $89.99 USD $7.00/mg
Modified Aminos 10 mg $69.99 USD $7.00/mg
Forge Performance Co 10 mg $70.00 USD $7.00/mg
Try Hero Research 10 mg $70.00 USD $85.00 USD $7.00/mg
AMC Essentials 20 mg $144.99 USD $7.25/mg
Puratek Peptides 10 mg $72.95 USD $7.29/mg
Go Alpha Labs 10 mg $74.99 USD $99.99 USD $7.50/mg
GenPeptide 5 mg $40.00 USD $8.00/mg
Crownwell Research 10 mg $80.00 USD $8.00/mg
ezPeps 11 mg $94.99 USD $119.99 USD $8.64/mg
Legendary Peptides 10 mg $87.00 USD $8.70/mg
EZ Peptides 5 mg $44.00 USD $8.80/mg
Ameano Peptides 10 mg $88.00 USD $8.80/mg
EZ Peptides 10 mg $88.00 USD $8.80/mg
peptidegiants.com 10 mg $89.99 USD $9.00/mg
Trusted Aminos 10 mg $89.99 USD $9.00/mg
Royal Peptides 10 mg $90.00 USD $9.00/mg
Triumphant Labs 10 mg $90.00 USD $9.00/mg
Puratek Peptides 5 mg $45.95 USD $9.19/mg
Athena Peptides 10 mg $95.00 USD $9.50/mg
Oath Peptides 10 mg $95.00 USD $195.00 USD $9.50/mg
Oath Research 10 mg $95.00 USD $195.00 USD $9.50/mg
Modern Aminos 10 mg $95.20 USD $9.52/mg
Oneday Compounds 5 mg $47.99 USD $59.99 USD $9.60/mg
peptidegiants.com 5 mg $48.00 USD $9.60/mg
Ameano Peptides 5 mg $49.00 USD $9.80/mg
Ion Peptide 10 mg $99.00 USD $9.90/mg
Xcel Peptides ships worldwide 10 mg $99.00 USD $9.90/mg
Fusion Peptide 8 mg $79.99 USD $10.00/mg
Rivn Peptides 10 mg $99.99 USD $10.00/mg
Titan X Research 10 mg $99.99 USD $10.00/mg
Valor Peptides 10 mg $99.99 USD $10.00/mg
PeakForm Peptides 10 mg $100.00 USD $10.00/mg
Peptides Warehouse 10 mg $101.59 USD $10.16/mg
aminousa 10 mg $102.00 USD $170.00 USD $10.20/mg
Treasure Coast Solutions 5 mg $51.50 USD $79.99 USD $10.30/mg
AMC Essentials 15 mg $154.99 USD $10.33/mg
Licensed Peptides 10 mg $109.99 USD $11.00/mg
Platinum Lion Peptides 10 mg $109.99 USD $125.00 USD $11.00/mg
Vortex Research 10 mg $109.99 USD $139.99 USD $11.00/mg
Athena Peptides 5 mg $55.00 USD $11.00/mg
milehighpeptides.com 5 mg $55.00 USD $11.00/mg
Peptide Crafters 10 mg $110.00 USD $11.00/mg
aminousa 5 mg $57.00 USD $95.00 USD $11.40/mg
Modern Aminos 8 mg $93.60 USD $11.70/mg
Ion Peptide 5 mg $59.00 USD $11.80/mg
PeakForce Labs 5 mg $59.00 USD $85.00 USD $11.80/mg
Hero Peptides 10 mg $119.00 USD $11.90/mg
Peptira 10 mg $119.00 USD $11.90/mg
Pure Peptide Labs 5 mg $59.95 USD $11.99/mg
Life Peptides 10 mg $119.95 USD $11.99/mg
Pure Peptide Labs 10 mg $119.95 USD $11.99/mg
Soma Chems 5 mg $59.99 USD $12.00/mg
PeakForm Peptides 5 mg $60.00 USD $70.00 USD $12.00/mg
Purus Peptides 5 mg $60.00 USD $12.00/mg
Jade Nexus 10 mg $120.00 USD $12.00/mg
Licensed Peptides 10 mg $122.99 USD $12.30/mg
Trulab Peptides 5 mg $62.00 USD $12.40/mg
Nationwide Peptides 10 mg $124.00 USD $12.40/mg
Soma - 10 mg $124.00 USD $12.40/mg
AMC Essentials 10 mg $124.99 USD $12.50/mg
PSPeptides 10 mg $125.99 USD $12.60/mg
Certified Peptides 10 mg $128.00 USD $12.80/mg
Arizona Peptides (.us) 5 mg $65.00 USD $75.00 USD $13.00/mg
Arizona Peptides USA 5 mg $65.00 USD $75.00 USD $13.00/mg
Nationwide Peptides 5 mg $65.00 USD $13.00/mg
Peptide Crafters 5 mg $65.00 USD $90.00 USD $13.00/mg
Pivot labs 10 mg $130.00 USD $13.00/mg
My GLP 1 Store 10 mg $132.00 USD $13.20/mg
Pure Bio Labs 10 mg $134.99 USD $13.50/mg
Hero Peptides 5 mg $69.00 USD $13.80/mg
Transforma Peptides 5 mg $69.00 USD $13.80/mg
Transforma Peptides 10 mg $139.00 USD $13.90/mg
Liberty Peptides 5 mg $72.00 USD $14.40/mg
My GLP 1 Store 5 mg $72.00 USD $14.40/mg
Valkyrie Peptides 10 mg $145.00 USD $14.50/mg
Pure Lab Peptides 10 mg $149.99 USD $15.00/mg
Florida Peptides 10 mg $150.00 USD $15.00/mg
Peptides.GG 10 mg $155.00 USD $15.50/mg
Protide Health 10 mg $155.00 USD $15.50/mg
Paramount Peptides 10 mg $157.25 USD $15.72/mg
Pure Lab Peptides 5 mg $79.99 USD $16.00/mg
Umbrella Labs 5 mg $79.99 USD $16.00/mg
Vital Core Research 10 mg $159.99 USD $16.00/mg
Florida Peptides 5 mg $80.00 USD $16.00/mg
Oasis Labs 5 mg $81.00 USD $16.20/mg
Pivot labs 5 mg $85.00 USD $17.00/mg
pepvidalabs 10 mg $170.00 USD $17.00/mg
USA Peptide Sciences 10 mg $170.00 USD $17.00/mg
Jade Nexus 5 mg $87.00 USD $17.40/mg
Modern Peptides 10 mg $178.00 USD $17.80/mg
PSPeptides 5 mg $89.99 USD $18.00/mg
pepvidalabs 5 mg $90.00 USD $18.00/mg
Pure Bio Labs 5 mg $94.99 USD $19.00/mg
Protide Health 5 mg $95.00 USD $19.00/mg
Pivot labs 10 mg $195.00 USD $19.50/mg
Xcel Peptides ships worldwide 5 mg $99.00 USD $19.80/mg
Vital Core Research 4 mg $79.99 USD $20.00/mg
AMC Essentials 20 mg $399.99 USD $20.00/mg
Peptides.GG 5 mg $100.00 USD $20.00/mg
BioGenix Peptides 5 mg $105.00 USD $21.00/mg
Modern Peptides 5 mg $105.00 USD $21.00/mg
Fusion Peptide 5 mg $106.99 USD $21.40/mg
PeptidesKingdom 10 mg $215.00 USD $21.50/mg
Licensed Peptides 5 mg $107.99 USD $21.60/mg
Vital Core Research 10 mg $225.99 USD $22.60/mg
milehighpeptides.com 5 mg $119.00 USD $23.80/mg
PeptidesKingdom 5 mg $125.00 USD $25.00/mg
Umbrella Labs 5 mg $129.99 USD $26.00/mg
Licensed Peptides 10 mg $273.87 USD $27.39/mg
Vital Core Research 4 mg $110.99 USD $27.75/mg
Regentide 5 mg $144.99 USD $170.00 USD $29.00/mg
Pivot labs 5 mg $149.00 USD $29.80/mg
Perform Peptides 10 mg $299.00 USD $29.90/mg
Fusion Peptide 2.5 mg $80.99 USD $32.40/mg
Licensed Peptides 10 mg $384.96 USD $38.50/mg
Jade Nexus 10 mg $430.00 USD $43.00/mg
Jade Nexus 5 mg $310.00 USD $62.00/mg
Licensed Peptides 10 mg $626.94 USD $62.69/mg
Fusion Peptide 1.4 mg $160.99 USD $114.99/mg
Eternal Peptides size not listed $46.99 USD $69.99 USD —
BioEdge Research Labs size not listed $59.00 USD —
Eternal Peptides size not listed $64.99 USD $89.99 USD —
VANDL Labs size not listed $79.99 USD —
milehighpeptides.com size not listed $89.00 USD —
ONYX BIOLABS size not listed $94.99 USD $129.99 USD —
Mile High Compounds size not listed $119.99 USD $129.99 USD —
TCORE BIOTECH size not listed $129.99 USD —
PeptidesKingdom size not listed $155.00 USD $185.00 USD —
American Peptides size not listed $170.00 USD —
Vital Core Research size not listed $232.99 USD —
Royal Peptides size not listed $300.00 USD —
PeptideTest size not listed $400.00 USD —
Royal Peptides size not listed $465.00 USD —
Listed in CAD
VendorSizePricePer mg
Panda Peptide 10 mg $79.99 CAD $8.00/mg
Nox Peptides 10 mg $99.99 CAD $10.00/mg
VPeptide Canada 10 mg $99.99 CAD $10.00/mg
Great Northern Peptides 10 mg $100.00 CAD $10.00/mg
PeptideProCanada 10 mg $100.00 CAD $125.00 CAD $10.00/mg
Riptide Peptides 10 mg $100.00 CAD $10.00/mg
Panda Peptide 5 mg $50.99 CAD $10.20/mg
Peptigo 5 mg $55.00 CAD $11.00/mg
Peptide Cart 5 mg $59.99 CAD $12.00/mg
Peptide Shop Canada 10 mg $127.50 CAD $12.75/mg
Luxara Labs 10 mg $130.00 CAD $13.00/mg
Canada Steroid Depot 11 mg $146.30 CAD $13.30/mg
Ronin Peptides 10 mg $139.99 CAD $14.00/mg
Peptide Shop Canada 5 mg $72.50 CAD $14.50/mg
Toronto Peptides 10 mg $150.00 CAD $15.00/mg
Luxara Labs 5 mg $80.00 CAD $16.00/mg
Black Helix Labs 10 mg $170.00 CAD $17.00/mg
Toronto Peptides 5 mg $100.00 CAD $132.00 CAD $20.00/mg
Canada Steroid Depot 10 mg $214.99 CAD $21.50/mg
Canadian Anabolics size not listed $90.00 CAD —

Prices are the vendor's own listing, reproduced with the date we read it — never converted between currencies, and compared per milligram only where the vendor states the vial size.

Share this record

Share card for Cagrilintide: structure, evidence rung and sources on file
www.peptidecorpus.com/peptides/cagrilintide