Tissue Repair & Regeneration
Hyaluronic Acid Binding Peptide
A healthy joint keeps a slippery layer on the cartilage surface, and lubricin is the protein that holds it there. The hyaluronic acid binding peptide is an engineering answer to losing it: one end grips hyaluronic acid, a paired collagen-binding peptide grips the cartilage, and the lubricant stays tethered where it is wanted. It has been tested in osteoarthritis models, in collagen hydrogels, and in an artificial synovial membrane built on electrospun scaffolds. It has never been given to a person: every study on file is animal or cell-culture work, no human dose exists, and eight identity fields including the sequence are empty.
Last updated
Mechanism
Tethers hyaluronic acid to the cartilage surface through a paired collagen-binding peptide, mimicking lubricin boundary lubrication.
Reported effects
What sources associate with this compound. Reported categories, not outcomes we have graded — each would need its own citation and rung.
- Cartilage lubrication research
- Osteoarthritis models
- Hyaluronic acid retention
Dosing on file unverified
No established human dose
Carried from a source that labels it unverified, and reproduced with that label attached. A record of what is reported, not a recommendation. No citation on this page establishes it.
Literature on file 6
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animal in vivo
A hyaluronic acid binding peptide-polymer system for treating osteoarthritis (2018, cited 92x) graded on: an animal model — read from the indexed abstract — “mice”
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review or editorial
Supramolecular Host-Guest Hydrogels for Corneal Regeneration. graded on: indexed as "review-article" - secondary literature, not a study — “review-article”
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in vitro
Neonatal and Adult Dermal Fibroblasts Remodel Hyaluronan Enriched Pericellular Matrix Differentially in Hyaluronic Acid Binding Peptide-Tethered Collagen Hydrogels. graded on: an in-vitro system — read from the indexed abstract — “cultured”
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in vitro
Hyaluronic Acid Binding Peptide Regulates Extracellular Matrix Deposition and Diminishes Fibroblast Contractility. graded on: fibroblast ECM deposition and contractility in HABP-functionalised culture — read from the abstract — “abstract review”
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in vitro
Developing an Artificial Synovial Membrane Model Using Hyaluronic Acid-Binding Peptides. graded on: an in-vitro system — read from the indexed abstract — “cell culture”
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animal in vivo
Chondrogenic potential of superficial versus cartilage layer cells of the temporomandibular joint condyle in photopolymerizable gelatin-based hydrogels. graded on: an animal model — read from the indexed abstract — “goats”
Notes unverified prose
No human clinical trials identified for therapeutic use; preclinical only; No human clinical trials identified
Not on file 10
8 of the 8 fields we track hold nothing on this record, and each says why. 2 further absences are named below. A blank field is a bug; a named absence is a finding.
- molecular weightnothing we hold supplies it
- molecular formulanothing we hold supplies it
- CAS registry numbernothing we hold supplies it
- PubChem identifiernothing we hold supplies it
- amino-acid sequencenothing we hold supplies it
- SMILES stringnothing we hold supplies it
- InChInothing we hold supplies it
- InChI keynothing we hold supplies it
- half-lifenothing we hold supplies it
- route of administrationnothing we hold supplies it
Each field links to every other record missing the same thing. The full ledger holds 765 gaps across 163 records.