Condition
Premature LH surge
2 compounds were checked against premature lh surge, and every one of them earned a row.
Last updated
Compounds with a graded row
Ordered by rung, strongest first. The rung rates the study design; the chip beside it says what the study measured. Both are needed.
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Cetrorelix
human RCT Direct outcome Approved for this condition
- Who was studied
- women aged 19-40 (mean 32) undergoing controlled ovarian stimulation, n=732 across five trials (two Phase 2, three Phase 3); PCOS, low or absent ovarian reserve, and stage III-IV endometriosis excluded
FDA-approved indication is "the inhibition of premature LH surges in women undergoing controlled ovarian stimulation" — this condition is the registrational endpoint itself, not an adjunct measure. In the label's clinical trials a premature LH surge (LH >= 10 U/L with progesterone >= 1 ng/mL) occurred in 0 of 115 women on the single 3 mg dose, 1.9% of 159 on 0.25 mg daily in the comparative study, and 1.0% of 303 in the non-comparative study.
Source DailyMed — the FDA label 1 primary source read for this row
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Ganirelix
human RCT Direct outcome Approved for this condition
- Who was studied
- women undergoing controlled ovarian hyperstimulation, multicentre open-label randomised study, n=463 on ganirelix 250 mcg subcutaneously daily from day 6 of recombinant FSH, with a luteal-phase GnRH agonist as reference
FDA-approved indication is "the inhibition of premature LH surges in women undergoing controlled ovarian hyperstimulation" — on this condition the registrational endpoint is the outcome itself: a premature LH surge before hCG (LH rise >= 10 mIU/mL with progesterone > 2 ng/mL or a significant oestradiol decline) occurred in under 1% of the 463 subjects. The same trial graded as a process measure on the assisted-reproduction page is direct evidence here.
Source DailyMed — the FDA label 1 primary source read for this row
Every compound checked earned a row
Nothing was checked against premature lh surge and set aside. That is unusual — most conditions here have a list at the bottom of this page.
What this page does not say
It reports what was measured, in whom, and how directly. It does not say what to take or at what dose, and a row here is a record of a study rather than a reason to use anything. Every rung links to the rubric that assigned it.