ARA-290

Mechanism

Activates innate repair receptor signaling and tissue-protective pathways.

Reported effects

What sources associate with this compound. Reported categories, not outcomes we have graded — each would need its own citation and rung.

• Neuropathic discomfort support
• Nerve recovery
• Sleep quality

Reconstitution

mass ÷ diluent = concentration; dose ÷ concentration = volume; volume × the syringe factor = units on the barrel (100 for U-100, 40 for U-40). Run your own numbers.

Half-life, storage & sport

Elimination half-life

~2 min (mice) — study. Npj imaging 2025; mice and rats.

The half-life on file is 2 min, measured in mice. On the schedule this record states — daily — each dose has fallen to under 0.1% of its own peak by the time the next is given. Nothing accumulates, and there is no loading phase to run.

The measurement is not human. It was made in mice, and small mammals clear peptides faster than people do — so this is the fastest plausible shape rather than the expected one.

The rise is not modelled and the axis is not a blood level. No absorption rate constant and no volume of distribution are on file, so each dose appears at full height the instant it is given, and the axis is percent of this compound's own peak.

Literature on file 7

• review or editorial
  Peptide-Based Approaches for Pain Relief and Healing in Wounds. graded on: indexed as "review-article" - secondary literature, not a study — “review-article”
• review or editorial
  Non-hematopoietic roles of erythropoietin in inflammation and metabolic disorders. graded on: indexed as "review-article" - secondary literature, not a study — “review-article”
• review or editorial
  Effects of Peptides and Bioactive Peptides on Acute Kidney Injury: A Review Study. graded on: indexed as "review-article" - secondary literature, not a study — “review-article”
• review or editorial
  Beyond perfusion: a review of peptide radiopharmaceuticals for cardiovascular imaging. graded on: indexed as "review-article" - secondary literature, not a study — “review-article”
• animal in vivo
  Immunometabolic dysregulation drives selective executive cognitive dysfunction in male db/db mice. graded on: an animal model — “mice”

Not graded

2 citations whose study design could not be read from the title. Left ungraded rather than guessed at.

• not graded
  NCT02070783: The Effects of ARA290 on the Cognitive and Neural Processing of Emotions in Healthy Volunteers graded on: NCT02070783 is completed and has posted no results - a registration, not a reported outcome — “NCT02070783”
• not graded
  NCT06626971: A Phase II Clinical Trial on the Use of ARA 290 for the Treatment of Diabetic Macular Oedema graded on: NCT06626971 is terminated and has posted no results - a registration, not a reported outcome — “NCT06626971”

Identity

PubChem CID 91810664 computed 3D conformer

Skeletal formulathe canonical depiction

Drawn by PubChem from CID 91810664, the identifier on this record.

Molecular weight

1257.3

Molecular formula

C51H84N16O21

CAS number

1208243-50-8

PubChem CID

91810664

InChI key

WZTIQQBMSJTRBR-WYKNNRPVSA-N

Sequence

XEQLERALNSS

SMILES

C[C@@H](C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(=O)N)C(=O)N[C@@H](CO)C(=O)N[C@@H](CO)C(=O)O)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCC(=O)N)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@@H]1CCC(=O)N1

InChI

InChI=1S/C51H84N16O21/c1-22(2)17-30(47(84)65-32(19-36(53)71)48(85)66-33(20-68)49(86)67-34(21-69)50(87)88)63-40(77)24(5)57-41(78)25(7-6-16-56-51(54)55)59-43(80)29(11-15-39(75)76)62-46(83)31(18-23(3)4)64-45(82)27(8-12-35(52)70)60-44(81)28(10-14-38(73)74)61-42(79)26-9-13-37(72)58-26/h22-34,68-69H,6-21H2,1-5H3,(H2,52,70)(H2,53,71)(H,57,78)(H,58,72)(H,59,80)(H,60,81)(H,61,79)(H,62,83)(H,63,77)(H,64,82)(H,65,84)(H,66,85)(H,67,86)(H,73,74)(H,75,76)(H,87,88)(H4,54,55,56)/t24-,25-,26-,27-,28-,29-,30-,31-,32-,33-,34-/m0/s1

Classified as

Innate Repair Receptor Signalingmechanism

It is one of the clearest cases on the site of a mechanism designed to separate a wanted effect from an unwanted one, so records here should be read for whether that separation was demonstrated rather than merely intended.

Also called

• ARA-290
• Cibinetide
• Pglu-glu-gln-leu-glu-arg-ala-leu-asn-ser-ser
• Phbsp
• cibinetida

Listed prices 132

What 96 shops we track listed for ARA-290, read from their own public catalogues on 2026-09-14. We take no commission on these and they are not ranked by any payment — how vendors are scored.

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