Sleep, Mood & Stress
Agouti-Related Protein (AgRP)
Agouti-related protein, written AgRP, is made by a small cluster of hypothalamic neurons whose function is to generate hunger. It does this by blocking the melanocortin MC3 and MC4 receptors that carry the fullness signal — the same receptors the newer weight-loss drugs push the other way, and mouse work on file reports that AgRP neurons are required for glucagon-like peptide-1 (GLP-1) receptor agonists to lower weight at all. Nobody is given AgRP: injected into rat brain it raises food intake, and in people it is read in blood as an index of energy balance and glucocorticoid activity rather than administered.
Last updated
Mechanism
Antagonises and inverse-agonises melanocortin MC3 and MC4 receptors, lowering melanocortin tone and raising food intake.
Reported effects
What sources associate with this compound. Reported categories, not outcomes we have graded — each would need its own citation and rung.
- Appetite regulation research
- Energy balance marker
- Glucocorticoid signalling context
Dosing on file unverified
No established human dose; biomarker only
Carried from a source that labels it unverified, and reproduced with that label attached. A record of what is reported, not a recommendation. No citation on this page establishes it.
Literature on file 6
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animal in vivo
AgRP reflects glucocorticoid action: integrated experimental and clinical evidence. graded on: an animal model — read from the indexed abstract — “mice”
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animal in vivo
Cyclic neuronostatin regulates glucose homeostasis and food intake through GPR107 phosphorylation. graded on: an animal model — read from the indexed abstract — “mice”
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animal in vivo
Exercise attenuates cisplatin-induced anorexia-cachexia via modulation of hypothalamic inflammation and orexigenic signaling. graded on: an animal model — read from the indexed abstract — “mice”
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animal in vivo
AgRP neurons are required for the weight-lowering effects of GLP-1 receptor agonists in female mice. graded on: an animal model — “mice”
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animal in vivo
Attenuated hypothalamic response to fructose via a dedicated gut-brain pathway. graded on: an animal model — read from the indexed abstract — “mice”
Not graded
1 citation whose study design could not be read from the title. Left ungraded rather than guessed at.
- not graded
Identity
- UniProt
- O00253 (precursor)
Notes unverified prose
No therapeutic dosing; studied as biomarker in obesity; not approved as drug; biomarker only
Not on file 10
8 of the 8 fields we track hold nothing on this record, and each says why. 2 further absences are named below. A blank field is a bug; a named absence is a finding.
- molecular weightnothing we hold supplies it
- molecular formulanothing we hold supplies it
- CAS registry numbernothing we hold supplies it
- PubChem identifiernothing we hold supplies it
- amino-acid sequencenothing we hold supplies it
- SMILES stringnothing we hold supplies it
- InChInothing we hold supplies it
- InChI keynothing we hold supplies it
- half-lifenothing we hold supplies it
- route of administrationnot applicable to this compound
Each field links to every other record missing the same thing. The full ledger holds 765 gaps across 163 records.