Miscellaneous & Research; Sleep, Mood & Stress

Galanin

Galanin is one of the body's own signalling peptides, and it is unusual in what it does: it mostly turns other signals down rather than up, everywhere from the brain to the gut to the pancreas. That inhibitory role is why it appears in work on feeding, pain, mood and stress resilience — including a recent finding, taken from inside a randomised placebo-controlled psilocybin trial in major depression, that psilocybin therapy lowered galanin in cerebrospinal fluid alongside noradrenaline. The human record here is that biomarker measurement plus a handful of small infusion studies. Galanin was first isolated in 1983, and there is no approved use for it anywhere.

Last updated 12 August 2026

Studied forFeeding behaviour research · Nociception research · Neuroendocrine signalling context

Evidence on file1 human observational study · 1 animal study

Strongest sourceCSF galanin and noradrenaline downregulation by psilocybin therapy in major depressive disorder. (human observational study)

Mechanism

Acts at three G-protein-coupled receptors, GAL1 to GAL3, largely inhibiting neurotransmitter and hormone release.

Reported effects

What sources associate with this compound. Reported categories, not outcomes we have graded — each would need its own citation and rung.

Feeding behaviour research
Nociception research
Neuroendocrine signalling context

Dosing on file unverified

IV bolus: 4 x 50 µg administered hourly; IV infusion: 80 pmol/kg/min for 60 min

Carried from a source that labels it unverified, and reproduced with that label attached. A record of what is reported, not a recommendation. No citation on this page establishes it.

Literature on file 6

review or editorial
Galanin and Galanin Receptors (1999, cited 83x) graded on: indexed as "Review" - secondary literature, not a study — “Review”
review or editorial
Expression of the Galanin system in the human pancreas, pancreatitis, and pancreatic cancer: Association with nodal involvement and perineural invasion. graded on: indexed as "Review" - secondary literature, not a study — “Review”
review or editorial
Galanin receptor 2: A multifunctional modulator in neurological diseases - Structure, mechanisms, and therapeutic prospects. graded on: indexed as "Review" - secondary literature, not a study — “Review”
review or editorial
Re-thinking neuropeptide therapeutics: What Neuropeptide Y and Galanin teach us about stress, resilience, and drug design. graded on: indexed as "Review" - secondary literature, not a study — “Review”
human observational
CSF galanin and noradrenaline downregulation by psilocybin therapy in major depressive disorder. graded on: a secondary or post-hoc analysis — read from the indexed abstract — “secondary analysis”
animal in vivo
Intracerebroventricular and intranasal application of alarin reduces body weight in male rats. graded on: an animal model — “rats”

Identity

Space-filling 3D model of Galanin, carbon grey, nitrogen blue, oxygen red — Built from the SMILES on this record — the atoms and bonds are exact. The shape is **one computed low-energy pose**, not a measured structure: a flexible peptide in solution has no single conformation, and where the SMILES leaves a stereocentre undefined the pose commits to one arbitrarily. The skeletal formula below claims connectivity and nothing more, which is what we actually know.

2D chemical structure of Galanin — Built from the SMILES on this record — the atoms and bonds are exact. The shape is **one computed low-energy pose**, not a measured structure: a flexible peptide in solution has no single conformation, and where the SMILES leaves a stereocentre undefined the pose commits to one arbitrarily. The skeletal formula below claims connectivity and nothing more, which is what we actually know.

Molecular weight: 3157.4
Molecular formula: C139H210N42O43
CAS number: 88813-36-9
PubChem CID: 16133823
UniProt: P22466 (precursor)
InChI key: CBSXZYWGVAQSHI-RUKUCZSXSA-N
SMILES: C[C@H]([C@@H](C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(=O)N)C(=O)N[C@@H](CO)C(=O)N[C@@H](C)C(=O)NCC(=O)N[C@@H](CC1=CC=C(C=C1)O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)NCC(=O)N2CCC[C@H]2C(=O)N[C@@H](CC3=CNC=N3)C(=O)N[C@@H](C)C(=O)N[C@@H](C(C)C)C(=O)NCC(=O)N[C@@H](CC(=O)N)C(=O)N[C@@H](CC4=CNC=N4)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC5=CC=CC=C5)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(=O)N)C(=O)NCC(=O)N[C@@H](CC(C)C)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CO)C(=O)O)NC(=O)[C@H](CC6=CNC7=CC=CC=C76)NC(=O)CN)O
InChI: InChI=1S/C139H210N42O43/c1-65(2)38-84(165-121(206)86(40-67(5)6)166-123(208)88(43-75-31-33-79(188)34-32-75)161-106(193)55-151-114(199)70(11)157-131(216)97(59-182)175-127(212)95(49-104(144)191)170-122(207)87(41-68(7)8)173-136(221)112(72(13)186)180-130(215)90(159-105(192)51-141)44-76-52-150-81-27-19-18-26-80(76)81)116(201)154-58-109(196)181-37-23-30-101(181)134(219)172-91(45-77-53-147-63-155-77)120(205)158-71(12)115(200)178-111(69(9)10)135(220)153-57-108(195)162-94(48-103(143)190)126(211)168-92(46-78-54-148-64-156-78)125(210)164-83(29-22-36-149-139(145)146)119(204)174-98(60-183)132(217)167-89(42-74-24-16-15-17-25-74)124(209)176-99(61-184)133(218)171-96(50-110(197)198)128(213)163-82(28-20-21-35-140)118(203)169-93(47-102(142)189)117(202)152-56-107(194)160-85(39-66(3)4)129(214)179-113(73(14)187)137(222)177-100(62-185)138(223)224/h15-19,24-27,31-34,52-54,63-73,82-101,111-113,150,182-188H,20-23,28-30,35-51,55-62,140-141H2,1-14H3,(H2,142,189)(H2,143,190)(H2,144,191)(H,147,155)(H,148,156)(H,151,199)(H,152,202)(H,153,220)(H,154,201)(H,157,216)(H,158,205)(H,159,192)(H,160,194)(H,161,193)(H,162,195)(H,163,213)(H,164,210)(H,165,206)(H,166,208)(H,167,217)(H,168,211)(H,169,203)(H,170,207)(H,171,218)(H,172,219)(H,173,221)(H,174,204)(H,175,212)(H,176,209)(H,177,222)(H,178,200)(H,179,214)(H,180,215)(H,197,198)(H,223,224)(H4,145,146,149)/t70-,71-,72+,73+,82-,83-,84-,85-,86-,87-,88-,89-,90-,91-,92-,93-,94-,95-,96-,97-,98-,99-,100-,101-,111-,112-,113-/m0/s1

Also called

Galanin (Research)

Notes unverified prose

Small human studies: Murck et al. 2004 (n≈12); Small human IV studies (Murck et al. 2004)

Not on file 2

1 of the 8 fields we track hold nothing on this record, and each says why. 1 further absence is named below. A blank field is a bug; a named absence is a finding.

amino-acid sequencenothing we hold supplies it
half-lifenothing we hold supplies it

Each field links to every other record missing the same thing. The full ledger holds 765 gaps across 163 records.

Listed prices 1

What 1 shop we track listed for Galanin, read from their own public catalogues on 2026-09-14. We take no commission on these and they are not ranked by any payment — how vendors are scored.

Compare prices1 listing from 1 shop

Listed in CAD
Vendor	Size	Price	Per mg
VPeptide Canada	10 mg	$100.00 CAD	$10.00/mg

Prices are the vendor's own listing, reproduced with the date we read it — never converted between currencies, and compared per milligram only where the vendor states the vial size.

At a glance

Strongest rung: human observational
Citations: 6
Regulatory: Human research reported (unverified)
Route: Intravenous
Declared gaps: 2

Citations by rung

Strongest wins, never an average.