Humanin

Mechanism

Signals through formyl peptide receptor FPRL-1 and gp130 receptor complexes, and binds Bax and IGFBP-3 to suppress apoptosis.

Reported effects

What sources associate with this compound. Reported categories, not outcomes we have graded — each would need its own citation and rung.

• Neuroprotection research
• Cellular stress resistance
• Metabolic ageing context

Literature on file 6

• in vitro
  Zinc(II) binds to the neuroprotective peptide humanin (2006, cited 52x) graded on: cell-free spectroscopic titration of Zn(II) binding to humanin — read from the abstract — “abstract review”
• in vitro
  Network Topology and Interactomic Analysis Reveal the Regulatory Framework of the Humanin Protein Family (MTRNR2Lx Class). graded on: an in-vitro system — read from the indexed abstract — “in vitro”
• animal in vivo
  Humanin ameliorates diabetes-induced testicular damage in a streptozotocin-induced mouse model. graded on: an animal model — “mouse”
• animal in vivo
  Humanin peptide ameliorates reproductive dysfunction and restores neuroendocrine mechanisms in SSRI-treated male rats. graded on: an animal model — “rats”
• human observational
  Altered placental expression of small humanin-like peptides in gestational diabetes mellitus. graded on: placental SHLP1-6 expression in GDM pregnancies vs normoglycaemic controls — read from the abstract — “abstract review”
• animal in vivo
  Mitochondrial-derived peptide Humanin protects granulosa cells under oxidative conditions. graded on: an animal model — read from the indexed abstract — “rats”

What is circulated not evidence 4

Claims passed around in community guides and vendor copy, recorded because they circulate — not because they are true. Each is shown with the page it was read from and what this record actually holds. Checked 2026-08-24.

• unverified community data dose common nothing on file either way

  Community protocols start at 0.5 mg of the HNG analogue daily, subcutaneously in the morning, rising to 1-2 mg if tolerated, cycled eight to twelve weeks on and four to eight weeks off.

  Community protocols typically begin at 0.5 mg HNG daily during Week 1, advancing to 1–2 mg if well-tolerated.

  On the record No dose is on file for humanin at all: no figure, no unit, no cycle. A fully titrated milligram protocol circulates against a blank dosing record.

  Source 1 · Source 2

• unverified community data sourcing common nothing on file either way

  Guides distinguish native humanin, dosed at 1-3 mg two or three times weekly, from the more potent HNG analogue at 100-500 mcg per injection — a roughly tenfold difference between two products sold under the same name.

  Community protocols typically begin at 0.5 mg HNG daily during Week 1, advancing to 1–2 mg if well-tolerated.

  On the record The record holds a single "Humanin" entry with no analogue distinction, no entry for HNG and no alias covering it. A buyer cannot tell from the record which of two molecules with a tenfold dose difference they are looking at.

  Source 1 · Source 2

• unverified community data sourcing occasional agrees with the record

  One dosing guide states that no human clinical trial of exogenous humanin or HNG exists at all, and that every circulating protocol is extrapolated from animal pharmacokinetics, in vitro concentrations and community experience.

  No human clinical trials exist for exogenous humanin/HNG supplementation.

  On the record The record grades humanin an animal study, and the basis for that grade is unusually explicit: the cited study assayed placental tissue by qPCR after caesarean delivery, and no peptide was given to anyone. The record and the community agree that nobody has been dosed with this in a study.

  Source 1

• unverified community data side effect common nothing on file either way

  Humanin is described as generally well tolerated, with injection-site reactions and occasional mild fatigue the only effects named.

  Injection site reactions

  On the record No side effect is on file for humanin. "Well tolerated" is being asserted about a compound the record shows has never been administered to a person in a study.

  Source 1

Identity

PubChem CID 16131438 computed 3D conformer

Skeletal formulathe canonical depiction

Drawn by PubChem from CID 16131438, the identifier on this record.

Molecular weight

2687.2

Molecular formula

C119H204N34O32S2

CAS number

330936-69-1

PubChem CID

16131438

InChI key

DPEUWKZJZIPZKE-OFANTOPUSA-N

Sequence

MAPRGFSCLLLLTSEIDLPVKRRA

SMILES

CC[C@H](C)[C@@H](C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CC(C)C)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](C)C(=O)O)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CO)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CS)NC(=O)[C@H](CO)NC(=O)[C@H](CC2=CC=CC=C2)NC(=O)CNC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H]3CCCN3C(=O)[C@H](C)NC(=O)[C@H](CCSC)N

InChI

InChI=1S/C119H204N34O32S2/c1-19-65(14)92(112(180)144-81(54-90(160)161)104(172)145-82(52-63(10)11)115(183)153-46-29-37-87(153)110(178)149-91(64(12)13)111(179)139-72(32-23-24-41-120)97(165)136-74(35-27-44-130-119(126)127)98(166)135-73(34-26-43-129-118(124)125)96(164)133-67(16)116(184)185)150-99(167)75(38-39-89(158)159)137-106(174)84(57-155)147-113(181)93(68(17)156)151-105(173)79(51-62(8)9)142-101(169)77(49-60(4)5)140-100(168)76(48-59(2)3)141-102(170)78(50-61(6)7)143-108(176)85(58-186)148-107(175)83(56-154)146-103(171)80(53-69-30-21-20-22-31-69)134-88(157)55-131-95(163)71(33-25-42-128-117(122)123)138-109(177)86-36-28-45-152(86)114(182)66(15)132-94(162)70(121)40-47-187-18/h20-22,30-31,59-68,70-87,91-93,154-156,186H,19,23-29,32-58,120-121H2,1-18H3,(H,131,163)(H,132,162)(H,133,164)(H,134,157)(H,135,166)(H,136,165)(H,137,174)(H,138,177)(H,139,179)(H,140,168)(H,141,170)(H,142,169)(H,143,176)(H,144,180)(H,145,172)(H,146,171)(H,147,181)(H,148,175)(H,149,178)(H,150,167)(H,151,173)(H,158,159)(H,160,161)(H,184,185)(H4,122,123,128)(H4,124,125,129)(H4,126,127,130)/t65-,66-,67-,68+,70-,71-,72-,73-,74-,75-,76-,77-,78-,79-,80-,81-,82-,83-,84-,85-,86-,87-,91-,92-,93-/m0/s1

Also called

• Humanin (Longevity)
• Humanin (Neuroprotection)

Listed prices 47

What 22 shops we track listed for Humanin, read from their own public catalogues on 2026-09-14. We take no commission on these and they are not ranked by any payment — how vendors are scored.

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