Protocol
Running a mitochondrial protocol
What the record holds about the schedule for the mitochondrial peptides — which is a schedule for each of them and a half-life for none.
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1 of 5 hold a half-life measurement. A curve needs that and a schedule, which is why one line is drawn below and 4 members appear in the table with no line at all.
This page draws no curves, and that is the whole of what it has to say. Five compounds, five circulated or extrapolated daily schedules, and not one half-life on file for any of them. MOTS-c is the case worth naming: a ten-week titration ladder in 200 mcg steps is published in several places, it is arithmetic scaled from a mouse dose rather than anything a person was given, and there is no pharmacokinetic measurement anywhere to say whether a daily interval is short, long, or beside the point.
The schedule on file
Read the last column first. Four kinds of thing get printed as a dose in this category and they are not the same kind of fact: an approved label, a trial protocol, a figure the community circulates, and arithmetic done on an animal study. What each chip means.
| Compound | Schedule on file | Half-life | Accumulation | Where the schedule comes from |
|---|---|---|---|---|
| 5-Amino-1MQcurve | daily250-500 mcg daily | 6.9 hrat, oral | noneeach dose has cleared before the next arrives | extrapolated Read 3 circulated claims |
| NAD+circulated, contested | 3x a week50-250 mg 2-3x/week | not on filethe circulated figures disagree, so none is drawn | —needs a half-life and an interval from the same record | circulated Read 4 circulated claims |
| MOTS-ccirculated, contested | daily5-10 mg 2-3x/week | not on filethe circulated figures disagree, so none is drawn | —needs a half-life and an interval from the same record | extrapolated Read 11 circulated claimsThe ten-week ladder circulated for MOTS-c is arithmetic from an animal dose. No study administered it to a person, and every graded row this corpus holds for MOTS-c traces to one 2015 mouse paper. |
| Humaninschedule only | dailyNo validated human dose; community: 250 mcg - 1 mg/day SC, or 2-5 mg 2-3x/week; TBD (no validated human dose) | not on file | —needs a half-life and an interval from the same record | circulated Read 1 circulated claim |
| SS-31schedule only | daily5-10 mg daily | not on file | —needs a half-life and an interval from the same record | trial |
What the schedule does over time
Each line is one compound's amount in the body as a percentage of its own peak, from the first dose onwards. Compounds share a chart only when they share a dosing interval, because that is the only comparison the shape supports. Nothing here builds between doses; the multiplier is in the table above.
- 5-Amino-1MQ half-life 6.9 h, no accumulation
What the curves do not model
One half-life was measured in an animal. 5-Amino-1MQ (rat). Small mammals clear peptides faster than people do, so that curve is the fastest plausible shape rather than the expected one. The species is on every row above and on the compound's own record.
The rise is not modelled. No absorption rate constant is on file for anything here, so every dose appears at full height the instant it is given. A real subcutaneous injection takes hours to peak. The decay is measured; the vertical line at each dose is a placeholder for a shape there is nothing to draw.
The axis is percent of each compound's own peak, and it is not a blood level. No volume of distribution is on file for anything on this page, so no curve here can carry a concentration. Two lines both at 50% are two compounds each at half of their own maximum — not two equal amounts of anything, and not a comparison of potency.
What the evidence says, separately
This page is about the schedule. It says nothing about whether any of it works — that is graded row by row against a named condition, and it lives on the goal pages, each of which opens with how many compounds were checked before it says which earned a row.
- Anti ageing metabolic — the graded record for these outcomes, with the denominator it was drawn from
What this page does not say
It reports the schedules on file and what the measured half-lives imply about them. It does not recommend a compound, a dose, an interval or a combination, and a schedule appearing here is a record that somebody publishes it rather than a reason to run it. Three of the four source classes are not approvals of anything.
Lay this out as a week
The planner takes a list of compounds and turns it into administration days, with the vial maths and the same-syringe question answered per pairing.
- Open 5 compounds in the protocol builder — a week of administration days, built from the schedules above
- Check the same list in the stack checker — nine dimensions across every pairing, including the ones with nothing on record