Gastrointestinal Health
GIP (Gastric Inhibitory Peptide)
GIP, gastric inhibitory peptide, is one of the two gut hormones — the other is GLP-1, glucagon-like peptide-1 — that tell the pancreas to release insulin as soon as food arrives, before blood sugar has moved much. It is far more prominent now than it was, because tirzepatide works partly by acting at the GIP receptor. One of the sharpest findings about it is a failure: under a hyperglycaemic clamp, the insulin response to infused GIP was 54 per cent lower in people with type 2 diabetes than in matched controls, while GLP-1 kept most of its effect. GIP itself is not a treatment, and eight identity fields including its sequence are empty here.
Last updated
Mechanism
Activates the GIP receptor on beta cells to raise glucose-dependent insulin release, and on adipocytes to affect lipid storage.
Reported effects
What sources associate with this compound. Reported categories, not outcomes we have graded — each would need its own citation and rung.
- Incretin research
- Insulin secretion research
- Fat metabolism context
Dosing on file unverified
7, 20, 60 pmol/kg IV bolus; 1 pmol/kg/min IV infusion; 2 µg/kg/hr
Carried from a source that labels it unverified, and reproduced with that label attached. A record of what is reported, not a recommendation. No citation on this page establishes it.
Literature on file 6
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review or editorial
Physiology, Gastric Inhibitory Peptide graded on: indexed as "Study Guide" - secondary literature, not a study — “Study Guide”
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human observational
Hormonal Modulation of Fat Mass Induced Insulin Resistance. graded on: a secondary or post-hoc analysis — read from the indexed abstract — “Subgroup analysis”
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animal in vivo
Acute peripheral versus central inhibition of insulin receptors differentially alters cytokine and blood-brain barrier responses to an inflammatory stimulus. graded on: an animal model — read from the indexed abstract — “mice”
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human observational
Hybrid Laparoscopic-Endoscopic Partial Jejunal Diversion with Magnetic Anastomosis in Obesity and Type 2 Diabetes: Durable 3-Year Metabolic Results. graded on: single-arm prospective first-in-human pilot, n=10, 36-month within-subject outcomes — read from the abstract — “abstract review”
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human case series
Diabetic ketoacidosis in a patient with type I diabetes treated with tirzepatide. graded on: single published case report (title-declared); abstract not indexed — read from the abstract — “abstract review”
Not graded
1 citation whose study design could not be read from the title. Left ungraded rather than guessed at.
- not graded
Identity
- UniProt
- P09681 (precursor)
Notes unverified prose
Human studies: dose-dependent glucagon stimulation; Human IV dose-response studies
Not on file 9
8 of the 8 fields we track hold nothing on this record, and each says why. 1 further absence is named below. A blank field is a bug; a named absence is a finding.
- molecular weightnothing we hold supplies it
- molecular formulanothing we hold supplies it
- CAS registry numbernothing we hold supplies it
- PubChem identifiernothing we hold supplies it
- amino-acid sequencenothing we hold supplies it
- SMILES stringnothing we hold supplies it
- InChInothing we hold supplies it
- InChI keynothing we hold supplies it
- half-lifenothing we hold supplies it
Each field links to every other record missing the same thing. The full ledger holds 765 gaps across 163 records.
Listed prices 2
What 1 shop we track listed for GIP (Gastric Inhibitory Peptide), read from their own public catalogues on 2026-09-14. We take no commission on these and they are not ranked by any payment — how vendors are scored.
Compare prices2 listings from 1 shop
| Vendor | Size | Price | Per mg |
|---|---|---|---|
| A2Z Peptides | 60 mg | $134.50 USD | $2.24/mg |
| A2Z Peptides | 20 mg | $121.90 USD | $6.09/mg |
None of these shops lists your destination. Choose “Show all” to see every listing we hold.
Prices are the vendor's own listing, reproduced with the date we read it — never converted between currencies, and compared per milligram only where the vendor states the vial size.