Condition
Joint pain
3 compounds were checked against joint pain. 2 earned a graded row; the rest are named below.
Last updated
Recorded under Pain, alongside 1 other indication.
Compounds with a graded row
Ordered by rung, strongest first. The rung rates the study design; the chip beside it says what the study measured. Both are needed.
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Collagen Peptides
human RCT Direct outcome Not approved for this condition
- Who was studied
- adults aged 40-75 with mild to moderate knee osteoarthritis (Kellgren-Lawrence grade I-III), pooled n=507 across 4 randomised placebo-controlled trials; oral hydrolysed collagen peptides 2-10 g daily for 90-180 days
A meta-analysis of four randomised placebo-controlled trials pooled 100 mm visual analogue scale knee pain scores and reported a standardised mean difference of -0.58 (p = 0.004) favouring oral collagen peptides, graded moderate quality. The joint studied is the knee in osteoarthritis; no trial on file measured hip, hand, shoulder or inflammatory arthritis pain, and collagen peptides are a food ingredient with no regulatory approval for joint pain anywhere.
Source PubMed Central 1 primary source read for this row
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Cartilage Peptides
human case series Direct outcome Not approved for this condition
- Who was studied
- adults with moderate knee joint discomfort and loss of function consistent with osteoarthritis, n=33, 1000 mg fish cartilage hydrolysate orally once daily for 3 months; open-label, no control group
An exploratory, non-comparative, multi-centre open-label study measured the Knee injury and Osteoarthritis Outcome Score and reported improvement in the pain and function subscales. With no placebo arm and no randomisation the improvement cannot be separated from natural course or expectation, and the authors state the result needs confirmation in a randomised controlled trial. The population is knee osteoarthritis only; no data on other joints is on file.
Source PubMed Central 1 primary source read for this row
Checked, and nothing recorded
1 compound was checked against joint pain and produced no gradeable row.
A compound is here because someone looked and the sources did not support a row — not because nobody looked. Under the rubric, uncertainty resolves to no row, and a row resting on a vendor page or a clinic blog is worse than no row at all.
What this page does not say
It reports what was measured, in whom, and how directly. It does not say what to take or at what dose, and a row here is a record of a study rather than a reason to use anything. Every rung links to the rubric that assigned it.