Metabolic & Weight Management
Brinp-2 Related Peptide (BRP)
BRP is a twelve-amino-acid peptide the body cuts out of a brain protein called BRINP2, and it was found the other way round from usual: by a computational search predicting which fragments human prohormones ought to release, then testing the shortlist. In fasted mice, obese mice and minipigs it reduced food intake dose-dependently with no sign of nausea or aversion, and it did so without the leptin, GLP-1 receptor or MC4R pathways that every current obesity drug runs through. That is the whole of the interest, and also the whole of the record: no person has received BRP in any published study, and the corpus holds one animal paper.
Last updated
Mechanism
Cleaved from BRINP2 by PCSK1; cuts food intake with central FOS activation, independent of leptin, GLP-1 receptor, and MC4R.
Reported effects
What sources associate with this compound. Reported categories, not outcomes we have graded — each would need its own citation and rung.
- Food intake research
- Body weight research
- Non-incretin pathway research
Dosing on file unverified
TBD (animal: 5-20 mg/kg IP in mice)
Carried from a source that labels it unverified, and reproduced with that label attached. A record of what is reported, not a recommendation. No citation on this page establishes it.
Literature on file 1
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animal in vivo
Prohormone cleavage prediction uncovers a non-incretin anti-obesity peptide. graded on: an animal model — read from the indexed abstract — “Mice”
Notes unverified prose
Preclinical only; no human trials published as of 2026; Preclinical (mouse/minipig); no human trials as of 2026
Not on file 10
8 of the 8 fields we track hold nothing on this record, and each says why. 2 further absences are named below. A blank field is a bug; a named absence is a finding.
- molecular weightnothing we hold supplies it
- molecular formulanothing we hold supplies it
- CAS registry numbernothing we hold supplies it
- PubChem identifiernothing we hold supplies it
- amino-acid sequencenothing we hold supplies it
- SMILES stringnothing we hold supplies it
- InChInothing we hold supplies it
- InChI keynothing we hold supplies it
- half-lifenothing we hold supplies it
- route of administrationnothing we hold supplies it
Each field links to every other record missing the same thing. The full ledger holds 765 gaps across 163 records.