Epitalon

Mechanism

Associated with telomere, clock-gene, and melatonin modulation.

Reported effects

What sources associate with this compound. Reported categories, not outcomes we have graded — each would need its own citation and rung.

• Sleep quality
• Circadian rhythm
• Stress resilience

Reconstitution

mass ÷ diluent = concentration; dose ÷ concentration = volume; volume × the syringe factor = units on the barrel (100 for U-100, 40 for U-40). Run your own numbers.

Half-life, storage & sport

Elimination half-life

not on file — no primary pharmacokinetic study found.

Storage

Lyophilised: Stable at room temperature ~3 weeks; store desiccated below -18C. Reconstituted: Reconstitute in sterile 18 Mohm-cm H2O at >=100 ug/mL; 4C for 2-7 days; below -18C for future use; 0.1% HSA/BSA for long term. — source. ProSpec technical datasheet; corpus slug is epitalon (epithalon is an alias). Supplier handling recommendation for research-grade lyophilate, not a per-compound stability study.

In sport (WADA 2026)

Prohibited, at all times — S0 catch-all. the list Not named. No approval for human therapeutic use in the major regulatory jurisdictions. Slug is epitalon in content/corpus.json (requested as epithalon).

Literature on file 7

• animal in vivo
  Effect of epitalon on the lifespan increase in Drosophila melanogaster (Mechanisms of Ageing and Development 2000, cited 37x) graded on: Drosophila melanogaster lifespan, dosed in culture medium — read from the abstract — “abstract review”
• in vitro
  AEDG Peptide (Epitalon) Stimulates Gene Expression and Protein Synthesis during Neurogenesis: Possible Epigenetic Mechanism (Molecules 2020, cited 31x) graded on: human gingival mesenchymal stem cell differentiation — read from the abstract — “abstract review”
• review or editorial
  Therapeutic peptides in gerontology: mechanisms and applications for healthy aging. graded on: indexed as "review-article" - secondary literature, not a study — “review-article”
• review or editorial
  Overview of Epitalon-Highly Bioactive Pineal Tetrapeptide with Promising Properties. graded on: indexed as "review-article" - secondary literature, not a study — “review-article”
• animal in vivo
  LCP2 mediates SUV39H1-driven cellular senescence-related chemoresistance in natural killer/T-cell lymphoma. graded on: an animal model — read from the indexed abstract — “mice”
• in vitro
  Epitalon increases telomere length in human cell lines through telomerase upregulation or ALT activity. graded on: human cell lines, telomere length and telomerase activity — read from the abstract — “abstract review”
• in vitro
  The Antioxidant Tetrapeptide Epitalon Enhances Delayed Wound Healing in an in Vitro Model of Diabetic Retinopathy. graded on: an in-vitro system — “in Vitro”

What is circulated not evidence 5

Claims passed around in community guides and vendor copy, recorded because they circulate — not because they are true. Each is shown with the page it was read from and what this record actually holds. Checked 2026-08-24.

• unverified community data dose ubiquitous contradicts the record

  Short annual courses are the near-universal pattern, but the figures disagree sharply between sources: 2 mg a day for twenty consecutive days three times a year in one chart, 10 mg a day for ten days every six months in others, and about 5 mg a day for twenty days elsewhere.

  20 consecutive days, 3 times per year

  On the record The record holds 5-10 mg per administration daily on a cycle of 1.5 to 3 weeks, and marks the dosing unverified. The 5 and 10 mg figures fall inside the range on file and the 1.5-3 week window matches the ten-to-twenty-day courses. The 2 mg/day protocol is below the range on file, and nothing on file records cycles per year.

  Source 1 · Source 2 · Source 3

• unverified community data benefit ubiquitous nothing on file either way

  Telomerase activation and telomere elongation in human cells, and increased lifespan in animals, are the reasons given for taking it; the same guides concede that no human lifespan effect has been shown.

  Epitalon induces telomerase activity and telomere elongation in human fib

  On the record The record lists benefits as 'Sleep quality', 'Circadian rhythm' and 'Stress resilience' — nothing about telomeres or lifespan at all. Its grading rests on a Drosophila melanogaster lifespan study dosed in culture medium, read from the abstract. The community's headline reason for using this compound has no corresponding entry in the record, and the one lifespan citation on file is in fruit flies.

  Source 1 · Source 2

• unverified community data side effect common nothing on file either way

  Vivid dreams and evening drowsiness are frequently reported and are attributed in community sources to a melatonin effect.

  Vivid dreams -- frequently reported, consistent with enhanced melatonin

  On the record No side effect is on file for epitalon. The record does list 'Sleep quality' and 'Circadian rhythm' as benefits, which is the same phenomenon recorded as a wanted effect and not as an unwanted one; no melatonin mechanism is on file.

  Source 1

• unverified community data sourcing occasional agrees with the record

  At least one guide states that most of the supporting studies come from a single research group and that Western clinical trials are absent.

  Western clinical trials are absent

  On the record The record grades epitalon on animal evidence, resting on a Drosophila lifespan experiment read from the abstract. That is consistent with the absence of human trials; the single-group provenance is not on file.

  Source 1

• unverified community data stacking occasional nothing on file either way

  Stacking epitalon with MOTS-c is presented as a longevity protocol.

  20 consecutive days, 3 times per year

  On the record Nothing on file. The record holds no combination entry for epitalon with MOTS-c or with anything else.

  Source 1

Identity

PubChem CID 219042 computed 3D conformer

Skeletal formulathe canonical depiction

Drawn by PubChem from CID 219042, the identifier on this record.

Molecular weight

390.35

Molecular formula

C14H22N4O9

CAS number

307297-39-8

PubChem CID

219042

InChI key

HGHOBRRUMWJWCU-FXQIFTODSA-N

Sequence

AEDG

SMILES

C[C@@H](C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CC(=O)O)C(=O)NCC(=O)O)N

InChI

InChI=1S/C14H22N4O9/c1-6(15)12(25)17-7(2-3-9(19)20)14(27)18-8(4-10(21)22)13(26)16-5-11(23)24/h6-8H,2-5,15H2,1H3,(H,16,26)(H,17,25)(H,18,27)(H,19,20)(H,21,22)(H,23,24)/t6-,7-,8-/m0/s1

Classified as

Subcutaneousroute

This is the route the reconstitution arithmetic assumes. Mass divided by diluent volume gives concentration, dose divided by concentration gives volume, and volume in mL multiplied by 100 gives units on a U-100 barrel: 5 mg in 2 mL is 2.5 mg/mL, and 0.25 mg comes out at 0.1 mL, which is 10 units.

Also called

• DTXCID801381023
• DTXSID80952957
• Epitalon
• Epitalon (Longevity)
• Epitalon (Sleep)
• alanyl-glutamyl-aspartyl-glycine
• epithalone
• epithalon
• epithalon – at 50 percent off
• epithalon – at 30 percent off

Listed prices 313

What 183 shops we track listed for Epitalon, read from their own public catalogues on 2026-09-14. We take no commission on these and they are not ranked by any payment — how vendors are scored.

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