Metabolic & Weight Management
Obestatin
Obestatin is cut from the same precursor protein as ghrelin, and in 2005 it was announced as ghrelin's mirror image: one gene, one prohormone, a hunger signal and a fullness signal packaged together. It was an elegant idea and it is the reason anyone knows the name. It is also the part that did not survive. A later rat study found no effect on spontaneous eating in fed or food-restricted animals and no blocking of ghrelin, and the GPR39 receptor binding the original claim rested on has repeatedly failed to replicate, leaving obestatin's receptor unresolved two decades on. No human has been given it in any dosing trial on file; the record holds animal work and observational studies.
Last updated
Mechanism
Proposed as a GPR39 ligand opposing ghrelin, but that binding has repeatedly failed to replicate and its receptor is unresolved.
Reported effects
What sources associate with this compound. Reported categories, not outcomes we have graded — each would need its own citation and rung.
- Appetite regulation research
- Ghrelin axis context
- Tissue regeneration research
Dosing on file unverified
No established human dose (animal: 12.5-1000 nmol/kg)
Carried from a source that labels it unverified, and reproduced with that label attached. A record of what is reported, not a recommendation. No citation on this page establishes it.
Literature on file 6
-
review or editorial
Obestatin, obesity and diabetes (2009, cited 36x) graded on: indexed as "Review" - secondary literature, not a study — “Review”
-
human RCT
Impact of semaglutide withdrawal on cardiometabolic profile and physiology of energy balance: Recovery effects after semaglutide termination - The REST trial study protocol. graded on: names a randomised controlled trial — read from the indexed abstract — “randomized controlled”
-
review or editorial
Obestatin: canonical and unexpected functions. graded on: indexed as "review-article" - secondary literature, not a study — “review-article”
-
animal in vivo
Obestatin and Its Fragment Analog Nt8U Influence Levels of Satiety Peptides in Diet-Induced Obese Mice. graded on: an animal model — “Mice”
-
human observational
Metabolic dysfunction-associated steatotic liver disease and metabolic abnormalities are associated with age and serum des-acyl ghrelin among apparently healthy females: Findings from a whole gastroenteropancreatic hormones survey with path analysis. graded on: an observational human design — read from the indexed abstract — “cross-sectional”
Not graded
1 citation whose study design could not be read from the title. Left ungraded rather than guessed at.
- not graded
Notes unverified prose
No human dosing trials identified; preclinical only; No human therapeutic trials; observational studies only
Not on file 10
8 of the 8 fields we track hold nothing on this record, and each says why. 2 further absences are named below. A blank field is a bug; a named absence is a finding.
- molecular weightnothing we hold supplies it
- molecular formulanothing we hold supplies it
- CAS registry numbernothing we hold supplies it
- PubChem identifiernothing we hold supplies it
- amino-acid sequencenothing we hold supplies it
- SMILES stringnothing we hold supplies it
- InChInothing we hold supplies it
- InChI keynothing we hold supplies it
- half-lifenothing we hold supplies it
- route of administrationnothing we hold supplies it
Each field links to every other record missing the same thing. The full ledger holds 765 gaps across 163 records.