Metabolic & Weight Management

Amylin

Amylin is the hormone released alongside insulin at every meal, from the same beta cells, with almost none of the fame. It acts on the hindbrain to slow the stomach, blunt the glucagon rise after eating and register fullness, which is why the obesity field has turned to it as a second lever to pull beside the GLP-1 drugs. Its other name, islet amyloid polypeptide, marks a second identity: a 1994 Nature paper reported the peptide as toxic to cultured pancreatic islet cells. The human evidence on file belongs to its analogues, with pramlintide approved and cagrilintide and petrelintide in randomised trials, while native amylin infused into six volunteers moved nothing until concentrations passed ninety times the normal post-meal peak.

Last updated 12 August 2026

Studied forSatiety research · Postprandial glucose research · Body weight research

Evidence on file2 animal studies · 2 citations not yet graded

Strongest sourcePancreatic islet cell toxicity of amylin associated with type-2 diabetes mellitus (Nature 1994, cited 696x) (animal study)

Mechanism

Acts at hindbrain amylin receptors, slowing gastric emptying, suppressing postprandial glucagon, and increasing satiety.

Reported effects

What sources associate with this compound. Reported categories, not outcomes we have graded — each would need its own citation and rung.

Satiety research
Postprandial glucose research
Body weight research

Dosing on file unverified

Petrelintide: 0.04-9.0 mg SC weekly; Eloralintide: 1-3 mg SC weekly

Carried from a source that labels it unverified, and reproduced with that label attached. A record of what is reported, not a recommendation. No citation on this page establishes it.

Half-life, storage & sport

Elimination half-life: < 20 min (human, SC) — study. Diabetes therapy : research, treatment and education of diabetes and related disorders 2025.

The half-life on file is 20 min, measured subcutaneously. On the schedule this record states — weekly — each dose has fallen to under 0.1% of its own peak by the time the next is given. Nothing accumulates, and there is no loading phase to run.

Dosed weekly over 4 wk, each dose normalised to the first peak.

The rise is not modelled and the axis is not a blood level. No absorption rate constant and no volume of distribution are on file, so each dose appears at full height the instant it is given, and the axis is percent of this compound's own peak.

Literature on file 4

animal in vivo
Pancreatic islet cell toxicity of amylin associated with type-2 diabetes mellitus (Nature 1994, cited 696x) graded on: an animal model — read from the indexed abstract — “rats”
animal in vivo
Multiple Amylin Receptors Arise from Receptor Activity-Modifying Protein Interaction with the Calcitonin Receptor Gene Product (Molecular Pharmacology 1999, cited 407x) graded on: an animal model — read from the indexed abstract — “rat”

Not graded

2 citations whose study design could not be read from the title. Left ungraded rather than guessed at.

not graded
NCT06662539: A Randomized, Double-blind, Phase 2, Dose-finding Trial of Once Weekly Petrelintide Compared With Placebo in Participants With Obesity or Overweight With Weight Related Comorbidities graded on: NCT06662539 is completed and has posted no results - a registration, not a reported outcome — “NCT06662539”
not graded
NCT06144684: A Two-Part First-in-Human Study to Assess the Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of Single and Multiple Ascending Subcutaneous Doses of GUB014295 in Lean to Overweight or Obese But Otherwise Healthy Men and Women graded on: NCT06144684 is completed and has posted no results - a registration, not a reported outcome — “NCT06144684”

Identity

Space-filling 3D model of Amylin, carbon grey, nitrogen blue, oxygen red — Built from the SMILES on this record — the atoms and bonds are exact. The shape is **one computed low-energy pose**, not a measured structure: a flexible peptide in solution has no single conformation, and where the SMILES leaves a stereocentre undefined the pose commits to one arbitrarily. The skeletal formula below claims connectivity and nothing more, which is what we actually know.

2D chemical structure of Amylin — Built from the SMILES on this record — the atoms and bonds are exact. The shape is **one computed low-energy pose**, not a measured structure: a flexible peptide in solution has no single conformation, and where the SMILES leaves a stereocentre undefined the pose commits to one arbitrarily. The skeletal formula below claims connectivity and nothing more, which is what we actually know.

Molecular weight: 3903.3
Molecular formula: C165H261N51O55S2
CAS number: 122384-88-7
PubChem CID: 16132430
UniProt: P10997
InChI key: PLOPBXQQPZYQFA-AXPWDRQUSA-N
Sequence: KCNTATCATQRLANFLVHSSNNFGAILSSTNVGSNTY
SMILES: CC[C@H](C)[C@@H](C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N[C@@H](CO)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC(=O)N)C(=O)N[C@@H](C(C)C)C(=O)NCC(=O)N[C@@H](CO)C(=O)N[C@@H](CC(=O)N)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC1=CC=C(C=C1)O)C(=O)N)NC(=O)[C@H](C)NC(=O)CNC(=O)[C@H](CC2=CC=CC=C2)NC(=O)[C@H](CC(=O)N)NC(=O)[C@H](CC(=O)N)NC(=O)[C@H](CO)NC(=O)[C@H](CO)NC(=O)[C@H](CC3=CN=CN3)NC(=O)[C@H](C(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC4=CC=CC=C4)NC(=O)[C@H](CC(=O)N)NC(=O)[C@H](C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CCC(=O)N)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](C)NC(=O)[C@@H]5CSSC[C@@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N5)[C@@H](C)O)C)[C@@H](C)O)CC(=O)N)NC(=O)[C@H](CCCCN)N
InChI: InChI=1S/C165H261N51O55S2/c1-22-75(12)124(159(266)200-95(47-71(4)5)140(247)203-108(64-219)153(260)206-110(66-221)154(261)216-129(84(21)226)163(270)202-105(58-119(174)234)147(254)209-122(73(8)9)157(264)181-61-121(236)187-106(62-217)150(257)198-103(56-117(172)232)148(255)215-128(83(20)225)162(269)190-93(130(175)237)49-87-38-40-89(227)41-39-87)211-132(239)76(13)183-120(235)60-180-136(243)97(50-85-32-25-23-26-33-85)194-144(251)101(54-115(170)230)196-145(252)102(55-116(171)231)197-151(258)107(63-218)205-152(259)109(65-220)204-142(249)99(52-88-59-178-69-182-88)201-158(265)123(74(10)11)210-146(253)96(48-72(6)7)193-141(248)98(51-86-34-27-24-28-35-86)195-143(250)100(53-114(169)229)191-131(238)77(14)184-139(246)94(46-70(2)3)192-137(244)91(37-31-45-179-165(176)177)188-138(245)92(42-43-113(168)228)189-161(268)126(81(18)223)212-133(240)78(15)185-155(262)111-67-272-273-68-112(207-135(242)90(167)36-29-30-44-166)156(263)199-104(57-118(173)233)149(256)214-125(80(17)222)160(267)186-79(16)134(241)213-127(82(19)224)164(271)208-111/h23-28,32-35,38-41,59,69-84,90-112,122-129,217-227H,22,29-31,36-37,42-58,60-68,166-167H2,1-21H3,(H2,168,228)(H2,169,229)(H2,170,230)(H2,171,231)(H2,172,232)(H2,173,233)(H2,174,234)(H2,175,237)(H,178,182)(H,180,243)(H,181,264)(H,183,235)(H,184,246)(H,185,262)(H,186,267)(H,187,236)(H,188,245)(H,189,268)(H,190,269)(H,191,238)(H,192,244)(H,193,248)(H,194,251)(H,195,250)(H,196,252)(H,197,258)(H,198,257)(H,199,263)(H,200,266)(H,201,265)(H,202,270)(H,203,247)(H,204,249)(H,205,259)(H,206,260)(H,207,242)(H,208,271)(H,209,254)(H,210,253)(H,211,239)(H,212,240)(H,213,241)(H,214,256)(H,215,255)(H,216,261)(H4,176,177,179)/t75-,76-,77-,78-,79-,80+,81+,82+,83+,84+,90-,91-,92-,93-,94-,95-,96-,97-,98-,99-,100-,101-,102-,103-,104-,105-,106-,107-,108-,109-,110-,111-,112-,122-,123-,124-,125-,126-,127-,128-,129-/m0/s1

Notes unverified prose

Phase 1/2; NCT06662539; NCT06144684; Petrelintide Phase 2 (Roche); Cagrilintide + semaglutide trials

Not on file 0

All 8 tracked fields hold a value on this record: molecular weight and formula, CAS number, PubChem CID, amino-acid sequence, SMILES, InChI and InChI key.

Counted from the record itself, not from what a source said it was missing. 163 of 188 records still have at least one empty.

Listed prices 2

What 2 shops we track listed for Amylin, read from their own public catalogues on 2026-09-14. We take no commission on these and they are not ranked by any payment — how vendors are scored.

Compare prices2 listings from 2 shops

Listed in USD
Vendor	Size	Price	Per mg
Disguised Alpha	size not listed	$179.99 USD	—
LiveWell Peptides	size not listed	$179.99 USD	—

Prices are the vendor's own listing, reproduced with the date we read it — never converted between currencies, and compared per milligram only where the vendor states the vial size.

At a glance

Strongest rung: animal in vivo
Citations: 4
Regulatory: In or past clinical trials (verified)
Route: Subcutaneous (investigational analogs)
Declared gaps: 0

Running this

GLP-1 and incretin

How the class is run, with the source of every schedule beside it.

Citations by rung

animal in vivo2

Strongest wins, never an average.