Immune & Antimicrobial
RNase 7
RNase 7 is an enzyme with a misleading name. Keratinocytes release it onto the skin surface, where it is one of the main reasons healthy skin resists colonisation by Staphylococcus aureus — but the bacterial killing has little to do with the RNA-cutting job the name describes and proceeds independently of it; what does the damage is the protein's positive charge tearing at bacterial membranes. Block it with an antibody in skin extracts and the bacteria grow back. All of that was measured in cell cultures, laboratory-grown skin models and extracts: RNase 7 has never been administered to an animal or a person, and no clinical outcome — a wound clearing, an infection resolving — has been measured for it.
Last updated
Mechanism
A cationic RNase A superfamily protein that permeabilises microbial membranes; its antibacterial action is largely independent of ribonuclease activity.
Reported effects
What sources associate with this compound. Reported categories, not outcomes we have graded — each would need its own citation and rung.
- Skin host-defence research
- Broad-spectrum antimicrobial studies
- Innate immune signalling context
Dosing on file unverified
No established human dose; preclinical only
Carried from a source that labels it unverified, and reproduced with that label attached. A record of what is reported, not a recommendation. No citation on this page establishes it.
Literature on file 6
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review or editorial
RNase 7 Protects Healthy Skin from Staphylococcus aureus Colonization (2010, cited 75x) graded on: indexed as "Letter" - secondary literature, not a study — “Letter”
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animal in vivo
Ribonucleases of Mice and Men: Unveiling the Roles of the RNase A Superfamily in Host Defence. graded on: an animal model — “Mice”
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computational
Engineering human RNase 7 with an eosinophil RNase segment reveals determinants of cytotoxic and antimicrobial activity. graded on: a computational prediction — read from the indexed abstract — “molecular docking”
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in vitro
Role of human RNase 7 in neuronal and glial cell models: moving towards an unexpected new functional link. graded on: neuronal and glial cell-culture models — read from the abstract — “abstract review”
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human observational
Skin Barrier Dysfunction, Antimicrobial Peptide Alterations, and Microbiome Changes in Solid Cancer Patients Treated with Epidermal Growth Factor Receptor Inhibitors. graded on: an observational human design — read from the indexed abstract — “cohort”
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in vitro
Human keratinocytes and fibroblasts coordinate early cutaneous innate defenses against Candida auris. graded on: an in-vitro system — read from the indexed abstract — “in vitro”
Identity
- UniProt
- Q9H1E1
Notes unverified prose
No human therapeutic trials; patent applications exist; studied in UTIs; no approved product; preclinical
Not on file 10
8 of the 8 fields we track hold nothing on this record, and each says why. 2 further absences are named below. A blank field is a bug; a named absence is a finding.
- molecular weightnothing we hold supplies it
- molecular formulanothing we hold supplies it
- CAS registry numbernothing we hold supplies it
- PubChem identifiernothing we hold supplies it
- amino-acid sequencenothing we hold supplies it
- SMILES stringnothing we hold supplies it
- InChInothing we hold supplies it
- InChI keynothing we hold supplies it
- half-lifenothing we hold supplies it
- route of administrationnothing we hold supplies it
Each field links to every other record missing the same thing. The full ledger holds 765 gaps across 163 records.