Cardiovascular & General
Vaspin
Vaspin is a serpin released by fat tissue — one of the protein family whose work is jamming other enzymes, this one blocking kallikrein 7 — and it appears to improve insulin sensitivity by easing a form of internal strain in fat cells, the stress on the machinery that folds new proteins. It is studied almost entirely as a number in a blood sample: levels compared between people with and without obesity, psoriasis, chronic low back pain or pregnancy complications. Nothing on file records vaspin being given to a person. The record can say what the levels look like in disease, and nothing at all about what changing them would do.
Last updated
Mechanism
A serpin that inhibits kallikrein 7 and binds cell-surface GRP78, easing endoplasmic reticulum stress in adipose tissue.
Reported effects
What sources associate with this compound. Reported categories, not outcomes we have graded — each would need its own citation and rung.
- Insulin sensitivity research
- Obesity marker studies
- Glucose tolerance research
Dosing on file unverified
Not administered therapeutically; observational only; animal: 10 ng/mL in vitro
Carried from a source that labels it unverified, and reproduced with that label attached. A record of what is reported, not a recommendation. No citation on this page establishes it.
Literature on file 8
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review or editorial
Novel Adipokines in Critical Illness and Sepsis: Chemerin, Vaspin, and Omentin-1: A Comprehensive Evidence-Based Review. graded on: indexed as "Review" - secondary literature, not a study — “Review”
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review or editorial
SERPINA12 in skin: molecular mechanisms and roles in adipocytes, psoriasis, and palmoplantar keratoderma. graded on: indexed as "review-article" - secondary literature, not a study — “review-article”
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animal in vivo
Postnatal Developmental Localization of Vaspin/GRP78 in the Mouse Pituitary and its Evidence in Gonadotrophin Secretion. graded on: an animal model — “Mouse”
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human observational
Vaspin-Cytokine Interactions in Chronic Low Back Pain: Links Between Obesity, Inflammation, and Traction Therapy Response. graded on: prospective non-randomised comparison of women with obesity versus normal BMI, with baseline measures — read from the abstract — “abstract review”
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animal in vivo
PPARγ-dependent transcriptional regulation of Vaspin expression in adipocytes. graded on: an animal model — read from the indexed abstract — “mice”
Not graded
3 citations whose study design could not be read from the title. Left ungraded rather than guessed at.
- not graded
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not graded
NCT07320872: Correlation Between Vaspin Gene Polymorphism and Serum Vaspin Levels in Psoriasis Vulgaris and Its Relation to Pathogenesis and Risk of the Disease graded on: NCT07320872 is recruiting and has posted no results - a registration, not a reported outcome — “NCT07320872”
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not graded
NCT04455204: Implication of Adipokines, Inflammation, Insulin Resistance and Endothelial Dysfunction in the Pathogenesis of Preeclampsia and in Pregnancy Related Complications graded on: NCT04455204 is completed and has posted no results - a registration, not a reported outcome — “NCT04455204”
Identity
- UniProt
- Q8IW75 (precursor)
Notes unverified prose
Endogenous adipokine; no therapeutic dosing; no human trials as drug
Not on file 10
8 of the 8 fields we track hold nothing on this record, and each says why. 2 further absences are named below. A blank field is a bug; a named absence is a finding.
- molecular weightnothing we hold supplies it
- molecular formulanothing we hold supplies it
- CAS registry numbernothing we hold supplies it
- PubChem identifiernothing we hold supplies it
- amino-acid sequencenothing we hold supplies it
- SMILES stringnothing we hold supplies it
- InChInothing we hold supplies it
- InChI keynothing we hold supplies it
- half-lifenothing we hold supplies it
- route of administrationnot applicable to this compound
Each field links to every other record missing the same thing. The full ledger holds 765 gaps across 163 records.