Tissue Repair & Regeneration

Tripeptide-10 Citrulline

Decorin sits along a collagen fibril and keeps its diameter uniform — a structural editor rather than a builder. Tripeptide-10 citrulline, sold as Decorinyl, is a three-amino-acid ingredient built to imitate that job, and the claim made for it is unusual for a skincare peptide: not more collagen, but collagen of an even thickness. The supplier measures it that way too, reporting a fall in the standard deviation of fibril diameters. Exactly one reference is on file — a randomised study in 24 people testing the ingredient combined with acetyl hexapeptide-3, the peptide sold as Argireline — so nothing here separates the two.

Last updated 12 August 2026

Studied forSkin elasticity research · Collagen fibril organisation · Wrinkle appearance context

Evidence on file1 randomised human trial

Strongest sourceThe efficacy study of the combination of tripeptide-10-citrulline and acetyl hexapeptide-3. A prospective, ra… (randomised human trial)

Mechanism

Binds collagen fibrils in the manner of decorin, regulating fibrillogenesis and keeping fibril diameter uniform.

Reported effects

What sources associate with this compound. Reported categories, not outcomes we have graded — each would need its own citation and rung.

Skin elasticity research
Collagen fibril organisation
Wrinkle appearance context

Manufacturer’s claim vendor marketing

For a proprietary cosmetic ingredient the manufacturer is the originator — there is no upstream to defer to, and this is often the only description that exists. It is reproduced as an attributed claim, with the label its source gave it. It is not graded and it is not evidence — the graded studies are under Literature.

Vendor claim (ci.guide, manufacturer's clinical trials): "regulates fibrillogenesis and collagen fibril dimensions"; "modulates collagen fibrillogenesis, resulting in thinner, more uniform fibers"; "improvements in collagen fibre quality, a decrease in the standard deviation of collagen fibril diameters, and a 54% increase in skin suppleness within 28 days" (28 days; n= not stated).

Manufacturer: Lipotec
Sold as: Decorinyl

Source page — nofollow, because a vendor link is a reference here, not an endorsement.

Dosing on file unverified

0.01% liposomal cream, 1x/day (28 days); combination with acetyl hexapeptide-3

Carried from a source that labels it unverified, and reproduced with that label attached. A record of what is reported, not a recommendation. No citation on this page establishes it.

Literature on file 1

human RCT
The efficacy study of the combination of tripeptide-10-citrulline and acetyl hexapeptide-3. A prospective, randomized controlled study (J Cosmet Dermatol 2017) graded on: names a randomised controlled trial — “randomized controlled”

Identity

Space-filling 3D model of Tripeptide-10 Citrulline, carbon grey, nitrogen blue, oxygen red — Built from the SMILES on this record — the atoms and bonds are exact. The shape is **one computed low-energy pose**, not a measured structure: a flexible peptide in solution has no single conformation, and where the SMILES leaves a stereocentre undefined the pose commits to one arbitrarily. The skeletal formula below claims connectivity and nothing more, which is what we actually know.

2D chemical structure of Tripeptide-10 Citrulline — Built from the SMILES on this record — the atoms and bonds are exact. The shape is **one computed low-energy pose**, not a measured structure: a flexible peptide in solution has no single conformation, and where the SMILES leaves a stereocentre undefined the pose commits to one arbitrarily. The skeletal formula below claims connectivity and nothing more, which is what we actually know.

Molecular weight: 530.6
Molecular formula: C22H42N8O7
CAS number: 960531-53-7
PubChem CID: 90479646
InChI key: GKPMARPRXONRJX-BWJWTDLKSA-N
SMILES: CC[C@H](C)[C@@H](C(=O)N[C@@H](CCCNC(=O)N)C(=O)N)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CCCCN)N
InChI: InChI=1S/C22H42N8O7/c1-3-12(2)17(21(36)28-14(18(25)33)8-6-10-27-22(26)37)30-20(35)15(11-16(31)32)29-19(34)13(24)7-4-5-9-23/h12-15,17H,3-11,23-24H2,1-2H3,(H2,25,33)(H,28,36)(H,29,34)(H,30,35)(H,31,32)(H3,26,27,37)/t12-,13-,14-,15-,17-/m0/s1

Also called

Decorinyl
Tripeptide-10 Citrulline

Notes unverified prose

RCT (n=24): combination with acetyl hexapeptide-3 showed antiwrinkle efficacy; 28-day study (n=43, 0.01%): significant wrinkle improvement; PMID: 28150423; RCT with acetyl hexapeptide-3

Not on file 2

1 of the 8 fields we track hold nothing on this record, and each says why. 1 further absence is named below. A blank field is a bug; a named absence is a finding.

amino-acid sequencenothing we hold supplies it
half-lifenothing we hold supplies it

Each field links to every other record missing the same thing. The full ledger holds 765 gaps across 163 records.