Tissue Repair & Regeneration
Silk Peptides
Silk peptides are the two proteins of the silkworm cocoon, sericin and fibroin, broken into fragments and sold in creams and supplements for hydration and anti-ageing. The evidence on file points somewhere else entirely. The registered human trial tested silk peptide for immune function, and the animal work runs in that direction rather than the skin one: natural killer cell activation and maturation in mouse splenocytes, and reduced muscle loss in aged mice. The skin case rests on laboratory work — free-radical scavenging, tyrosinase inhibition, skin cells dividing — and because this is a hydrolysate rather than a defined molecule, no sequence or molecular weight can be recorded.
Last updated
Mechanism
Scavenge free radicals, inhibit tyrosinase, and stimulate keratinocyte and fibroblast proliferation with increased collagen I and III.
Reported effects
What sources associate with this compound. Reported categories, not outcomes we have graded — each would need its own citation and rung.
- Skin hydration research
- Antioxidant context
- Collagen synthesis research
Dosing on file unverified
SO1/SC1 peptide cream (28-day clinical trial)
Carried from a source that labels it unverified, and reproduced with that label attached. A record of what is reported, not a recommendation. No citation on this page establishes it.
Literature on file 7
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in vitro
Conformational Transitions in Model Silk Peptides (2000, cited 241x) graded on: an in-vitro system — read from the indexed abstract — “in vitro”
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in vitro
Effect of Metal-Phenolic Quinone Network on the Performance of Thermomechanical Processed Chitosan-Silk Peptide Biomimetic Films: Improved Mechanical and Antibacterial Properties. graded on: composite-film mechanical testing with antibacterial assays against S. aureus and E. coli — read from the abstract — “abstract review”
- animal in vivo
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animal in vivo
A thin film comprising silk peptide and cellulose nanofibrils implanting on the electrospun poly(lactic acid) fibrous scaffolds for biomedical reconstruction. graded on: an animal model — read from the indexed abstract — “rabbits”
- animal in vivo
Not graded
2 citations whose study design could not be read from the title. Left ungraded rather than guessed at.
- not graded
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not graded
NCT03739970: A Clinical Trial of Silk Peptide for the Evaluation of Efficacy on Immune Function Enhancement graded on: NCT03739970 is unknown and has posted no results - a registration, not a reported outcome — “NCT03739970”
Notes unverified prose
28-day clinical trial (n=30): silk-derived SO1/SC1 cream improved photoaging skin indicators (hydration, TEWL, roughness, luminosity, melanin); manufacturer-sponsored small studies; 28-day clinical trial (n=30): SO1/SC1 cream; Phase 0 RCT (SDOs)
Not on file 9
8 of the 8 fields we track hold nothing on this record, and each says why. 1 further absence is named below. A blank field is a bug; a named absence is a finding.
- molecular weightnothing we hold supplies it
- molecular formulanothing we hold supplies it
- CAS registry numbernothing we hold supplies it
- PubChem identifiernothing we hold supplies it
- amino-acid sequencenothing we hold supplies it
- SMILES stringnothing we hold supplies it
- InChInothing we hold supplies it
- InChI keynothing we hold supplies it
- half-lifenothing we hold supplies it
Each field links to every other record missing the same thing. The full ledger holds 765 gaps across 163 records.