Glutathione

Mechanism

Tripeptide redox buffer with NADPH-dependent recycling and phase-2 conjugation roles.

Reported effects

What sources associate with this compound. Reported categories, not outcomes we have graded — each would need its own citation and rung.

• Oxidative-stress support
• Detox substrate
• Mitochondrial function

Literature on file 11

• review or editorial
  GSH-Related Enzymes GPx4, Chac1, and GSTs and Redox Regulation of Ferroptosis in Cancer. graded on: indexed as "Review" - secondary literature, not a study — “Review”
• human observational
  A Glutathione Metabolism-Related Transcriptomic Signature for Prognostic Assessment and Biological Characterization of Lung Adenocarcinoma. graded on: an observational human design — read from the indexed abstract — “cohort”
• in vitro
  Reprogramming Glutathione-Binding Proteins into Artificial Photoenzymes by Engineered Glutathione-Type Cofactors. graded on: cell-free enzyme engineering and directed evolution of glutathione S-transferases — read from the abstract — “abstract review”
• animal in vivo
  Loki Zupa alleviates type 2-high acute asthma airway inflammation by regulating the glutathione metabolism-ferroptosis axis. graded on: an animal model — read from the indexed abstract — “mouse”
• animal in vivo
  Ferroptosis induction by curcumin through regulating the expression of glutathione peroxidase 4 in papillary thyroid carcinoma. graded on: an animal model — read from the indexed abstract — “mice”
• human RCT
  NCT02311907: The Use of Glutathione (GSH) for Prevention of Paclitaxel/Carboplatin (TAXOL/CBDCA) Induced Peripheral Neuropathy: A Phase III Randomized, Double-Blind Placebo Controlled Study graded on: a randomised study — “Randomized, Double-Blind Placebo Controlled Study”
• human observational
  NCT02251041: Combined Drug Approach to Prevent Ischemia-reperfusion Injury During Transplantation of Livers (CAPITL): a First-in-men Study graded on: a registered clinical study — “clinicaltrials.gov”
• human RCT
  NCT03020719: A Multi Center Placebo Controlled Double Blind Randomized Study Evaluating the Role of Oral Glutathione on Growth Parameters in Children With Cystic Fibrosis graded on: a randomised study — “Randomized Study”
• human observational
  NCT01402570: Oral Glutathione and Health Outcomes Among Persons With Post-Polio Syndrome graded on: a registered clinical study — “clinicaltrials.gov”
• human observational
  NCT02029521: Supplementation of Oral Reduced Glutathione in Pediatric Cystic Fibrosis for Growth Failure graded on: a registered clinical study — “clinicaltrials.gov”

Not graded

1 citation whose study design could not be read from the title. Left ungraded rather than guessed at.

• not graded
  Overview of Glutathione Function and Metabolism (1999, cited 5x)

Identity

PubChem CID 124886 computed 3D conformer

Skeletal formulathe canonical depiction

Drawn by PubChem from CID 124886, the identifier on this record.

Molecular weight

307.33

Molecular formula

C10H17N3O6S

CAS number

70-18-8

PubChem CID

124886

ChEMBL

CHEMBL1543

InChI key

RWSXRVCMGQZWBV-WDSKDSINSA-N

SMILES

C(CC(=O)N[C@@H](CS)C(=O)NCC(=O)O)[C@@H](C(=O)O)N

InChI

InChI=1S/C10H17N3O6S/c11-5(10(18)19)1-2-7(14)13-6(4-20)9(17)12-3-8(15)16/h5-6,20H,1-4,11H2,(H,12,17)(H,13,14)(H,15,16)(H,18,19)/t5-,6-/m0/s1

Also called

• Glutathione (GSH)

Listed prices 221

What 146 shops we track listed for Glutathione, read from their own public catalogues on 2026-09-14. We take no commission on these and they are not ranked by any payment — how vendors are scored.

Share this record