A family of proteins that regulate cellular health and longevity pathways. Sirtuins require NAD+ to function.

Why it matters here

Sirtuins are the link between an NAD+ number and a longevity claim, because they need NAD+ to work. A mechanism is not an outcome, and this corpus grades the study that was run rather than the reasoning that motivated it.

Also called

• sirtuin
• sirtuins
• sirt1
• sirt-1

Compounds carrying this term

None on file yet. This term is in the controlled vocabulary but no compound record currently uses it — which is a statement about our coverage, not about the term.

See also

• NAD+ Metabolism — Mechanism of Action
• Cellular Senescence — Biological Pathway
• Endogenous vs exogenous — Body and drug basics